Product image of Metformine Hcl Accord (Metformin Hydrochloride) supplied by GNH India

Metformine Hcl Accord

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Hcl Accord (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformine Hcl Accord, is a biguanide presented as an oral tablet for oral use. It is indicated to improve glycemic control in adults with type 2 diabetes mellitus, helping to lower elevated blood glucose levels and reduce HbA1c.

GNH India supplies Metformine Hcl Accord as a licensed, GDP‑compliant international pharmaceutical product, sourced from the European Union market, and provides it to hospitals, pharmacies and clinics worldwide under strict quality standards, ensuring consistent potency and safety.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Metformine Hcl Accord is a biguanide antidiabetic medication that acts on glucose metabolism.

  • Type 2 diabetes mellitus: improves glycemic control by lowering fasting plasma glucose and HbA1c.
  • Impaired glucose tolerance (prediabetes): helps reduce the risk of progression to overt diabetes.
  • Polycystic ovary syndrome (off‑label): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin Hydrochloride lowers hepatic glucose production by inhibiting mitochondrial respiratory-chain complex I, which reduces gluconeogenesis. It also enhances peripheral insulin sensitivity, increasing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal absorption of glucose, collectively improving blood glucose levels without stimulating insulin secretion.

Side Effects

Metformine Hcl Accord may cause a range of adverse reactions. Patients should be aware of both common and serious possibilities.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Abdominal discomfort: cramping or pain.
  • Metallic taste: altered taste perception.
  • Loss of appetite: reduced desire to eat.
  • Vomiting: occasional episodes.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe hypoglycemia: especially when combined with other glucose‑lowering agents.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hepatic dysfunction: rare liver injury.
  • Skin rash or hypersensitivity reactions.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Metformine Hcl Accord requires careful consideration of patient‑specific factors before and during therapy.

  • Renal function: assess eGFR before initiation and periodically thereafter.
  • Hepatic disease: avoid in patients with severe liver impairment.
  • Risk of lactic acidosis: contraindicated in conditions predisposing to hypoxia or reduced perfusion.
  • Pregnancy and lactation: use only if potential benefit justifies the potential risk.
  • Monitoring: regularly check HbA1c, renal function, and vitamin B12 status.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformine Hcl Accord can interact with several medications, necessitating vigilance.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure and lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol: heightens risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycemia.
  • Diuretics (especially thiazides): can affect renal clearance of metformin.
  • ACE inhibitors or ARBs: monitor renal function and electrolytes.

Frequently Asked Questions

Metformine Hcl Accord contains Metformin Hydrochloride, a biguanide antidiabetic agent used to improve blood glucose control in adults with type 2 diabetes mellitus and, in some cases, to manage impaired glucose tolerance.

Metformin reduces hepatic glucose production by inhibiting mitochondrial complex I, enhances peripheral insulin sensitivity, and modestly decreases intestinal glucose absorption, thereby lowering fasting and post‑prandial blood glucose levels without stimulating insulin secretion.

The exact dose of Metformine Hcl Accord is determined by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made according to individual needs.

Safety in pregnancy and lactation has not been fully established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Metformine Hcl Accord belongs to the biguanide class, which differs from sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors. It primarily reduces hepatic glucose output and improves insulin sensitivity, whereas other classes may increase insulin secretion, inhibit glucose reabsorption, or affect incretin pathways.

Store Metformine Hcl Accord at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Metformine Hcl Accord is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare provider.

The most serious risk is lactic acidosis, a rare but potentially fatal condition, especially in patients with renal impairment, hepatic disease, or severe infection. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort occur.

Metformine Hcl Accord is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or conditions that predispose to hypoxia such as severe heart failure or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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