Metformine Hcl Aurobindo

Active Ingredient:: Metformin Hydrochloride
Origin:: EU

Metformine Hcl Aurobindo (Metformin Hydrochloride)

Q: What is Metformine Hcl Aurobindo used for?

Metformine Hcl Aurobindo contains metformin hydrochloride and is used to improve blood glucose control in adults with type 2 diabetes mellitus, as well as in individuals with prediabetes to help delay progression to diabetes.

Q: How does metformin work in the body?

Metformin lowers blood sugar by reducing hepatic glucose production and increasing insulin‑mediated glucose uptake in muscle and fat cells, primarily through activation of the AMP‑activated protein kinase (AMPK) pathway.

Q: What is the usual dose of Metformine Hcl Aurobindo?

The exact dose is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Q: Is Metformine Hcl Aurobindo safe during pregnancy or breastfeeding?

Metformin is classified as pregnancy category unknown. It may be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, and breastfeeding mothers should consult their healthcare provider before use.

Q: How do I order Metformine Hcl Aurobindo from GNH India?

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Q: How does metformin compare with other antidiabetic drugs?

Metformin is often preferred as first‑line therapy for type 2 diabetes because it does not cause weight gain and has a low risk of hypoglycemia compared with sulfonylureas or insulin. It belongs to the biguanide class, whereas many alternatives are sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors.

Q: What are the recommended storage conditions for Metformine Hcl Aurobindo?

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Q: How is Metformine Hcl Aurobindo administered?

Metformine Hcl Aurobindo is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Q: What are the most serious risks associated with metformin?

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Q: Who should not use Metformine Hcl Aurobindo?

Metformine Hcl Aurobindo should be avoided in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those who have experienced lactic acidosis while on metformin.

Metformin, the active ingredient in Metformine Hcl Aurobindo, is a biguanide presented as an oral dosage form for oral use. It is used to lower elevated blood glucose levels in patients with type 2 diabetes mellitus and related glucose‑handling disorders.

GNH India supplies Metformine Hcl Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Metformin is indicated for conditions that involve impaired glucose regulation within the type 2 diabetes therapeutic pathway.
Type 2 diabetes mellitus: reduces fasting and post‑prandial blood glucose levels.
Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes.
Polycystic ovary syndrome (off‑label use): improves insulin sensitivity and may aid menstrual regularity.

How It Works

Metformin decreases hepatic gluconeogenesis and enhances peripheral glucose uptake by activating AMP‑activated protein kinase (AMPK). This dual action reduces endogenous glucose production and increases insulin‑mediated glucose utilization in muscle and adipose tissue, leading to lower circulating blood glucose concentrations without directly stimulating insulin secretion.

Side Effects

Metformin is generally well tolerated, but a range of adverse reactions have been reported.

Common Side Effects

Gastrointestinal upset (nausea, abdominal discomfort)
Diarrhea
Metallic taste in the mouth
Loss of appetite
Mild weight loss

Serious or Rare Side Effects

Lactic acidosis (rare but potentially fatal)
Severe hypoglycemia when combined with other glucose‑lowering agents
Hepatotoxicity (very rare)
Skin rash or hypersensitivity reactions

Precautions & Warnings

Metformin should be used with awareness of specific safety considerations.
Renal function assessment: avoid use in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²).
Lactic acidosis risk: discontinue before any radiologic contrast studies involving iodine.
Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
Alcohol consumption: limit intake as excessive alcohol may increase lactic acidosis risk.
Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metformin may interact with several medicines that affect its plasma concentration or increase the risk of adverse events.

Major Interactions (Avoid)

Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis.
Cimetidine: may increase metformin plasma levels.
Certain antiretrovirals (e.g., didanosine): heightened risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

Beta‑blockers: may mask hypoglycemia symptoms.
Diuretics (especially thiazides): can raise blood glucose.
ACE inhibitors or ARBs: monitor renal function when combined.

Frequently Asked Questions

Metformine Hcl Aurobindo contains metformin hydrochloride and is used to improve blood glucose control in adults with type 2 diabetes mellitus, as well as in individuals with prediabetes to help delay progression to diabetes.

Metformin lowers blood sugar by reducing hepatic glucose production and increasing insulin‑mediated glucose uptake in muscle and fat cells, primarily through activation of the AMP‑activated protein kinase (AMPK) pathway.

The exact dose is determined by the prescribing clinician based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Metformin is classified as pregnancy category unknown. It may be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, and breastfeeding mothers should consult their healthcare provider before use.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin is often preferred as first‑line therapy for type 2 diabetes because it does not cause weight gain and has a low risk of hypoglycemia compared with sulfonylureas or insulin. It belongs to the biguanide class, whereas many alternatives are sulfonylureas, DPP‑4 inhibitors, or SGLT2 inhibitors.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Metformine Hcl Aurobindo is taken orally, usually with meals to reduce gastrointestinal discomfort. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal impairment, hepatic disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformine Hcl Aurobindo should be avoided in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those who have experienced lactic acidosis while on metformin.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 06 Sep 2026

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