Product image of Metformine Hcl Teva (Metformin Hydrochloride) supplied by GNH India

Metformine Hcl Teva

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Hcl Teva (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformine Hcl Teva, is a biguanide presented as an oral dosage form for oral use. It treats type 2 diabetes mellitus in adult patients by improving blood‑glucose control.
GNH India supplies Metformine Hcl Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Metformine Hcl Teva is a biguanide antidiabetic used to manage disorders of glucose metabolism.

  • Type 2 diabetes mellitus: lowers fasting and post‑prandial blood glucose levels.
  • Impaired glucose tolerance: helps delay progression to overt diabetes.
  • Polycystic ovary syndrome: improves insulin resistance and may normalize menstrual cycles.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting hepatic gluconeogenesis, thereby reducing hepatic glucose output. It also enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue and modestly decreases intestinal glucose absorption, collectively improving glycaemic control without stimulating insulin secretion.

Side Effects

Metformine Hcl Teva may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often early in therapy.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Loss of appetite: reduced desire to eat.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatotoxicity: abnormal liver enzymes or liver injury.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hypoglycaemia: when combined with other glucose‑lowering agents.

Precautions & Warnings

Before initiating Metformine Hcl Teva, several safety considerations should be reviewed.

  • Renal function assessment: ensure adequate kidney clearance before use.
  • Hepatic function monitoring: avoid in significant liver disease.
  • Cardiovascular status: caution in patients with congestive heart failure.
  • Concomitant medications: review for drugs that may increase risk of lactic acidosis.
  • Gastrointestinal tolerance: advise patients to take with meals to reduce upset.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metformine Hcl Teva can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol: raises risk of lactic acidosis.
  • Carbonic anhydrase inhibitors (e.g., acetazolamide): may enhance renal accumulation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • Diuretics: can affect renal function and metformin clearance.
  • ACE inhibitors/ARBs: monitor renal function and electrolytes.
  • Oral contraceptives: may slightly increase metformin levels.

Frequently Asked Questions

Metformine Hcl Teva contains metformin hydrochloride, a biguanide oral antidiabetic medication. It is prescribed to improve blood‑glucose control in adults with type 2 diabetes mellitus and may also be used in certain cases of impaired glucose tolerance or polycystic ovary syndrome to address insulin resistance.

Metformin Hydrochloride lowers blood glucose primarily by suppressing hepatic gluconeogenesis, which reduces the amount of glucose released by the liver. It also increases peripheral insulin sensitivity, enhancing glucose uptake in muscle and fat tissue, and modestly reduces intestinal glucose absorption, together helping to normalize glycaemic levels.

The appropriate dose of Metformine Hcl Teva is determined individually by a qualified prescriber based on the patient’s clinical condition, renal function, and response to therapy. Dosage adjustments are made according to therapeutic goals and tolerability, and patients should follow the prescribing healthcare professional’s instructions.

Safety of metformin during pregnancy or lactation should be evaluated by a healthcare professional. While metformin is sometimes continued in pregnancy for specific indications, its use is decided case‑by‑case. Breastfeeding mothers should discuss potential exposure with their physician, as metformin does pass into breast milk in small amounts.

To request Metformine Hcl Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformine Hcl Teva belongs to the biguanide class, differing from sulfonylureas, DPP‑4 inhibitors or SGLT2 inhibitors. Unlike insulin‑secretagogues, metformin does not stimulate insulin release, reducing hypoglycaemia risk. It is often used as first‑line therapy because of its efficacy, weight‑neutral profile and low cost compared with newer agents.

Metformine Hcl Teva should be stored at room temperature, below 25 °C, in its original container to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

Metformine Hcl Teva is taken orally, usually with meals to minimise gastrointestinal upset. Tablets are swallowed whole with a glass of water. The exact timing and frequency are prescribed by the treating clinician, who may start with a low dose and titrate upward based on glycaemic response.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with significant renal impairment, hepatic disease, or excessive alcohol intake. Other serious concerns include severe skin reactions and vitamin B12 deficiency with long‑term use, which require regular monitoring.

Metformine Hcl Teva is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those with known hypersensitivity to metformin. Caution is also advised for individuals with significant liver disease or congestive heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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