Product image of Metformine Hydrochloride Aurobindo (Metformin Hydrochloride) supplied by GNH India

Metformine Hydrochloride Aurobindo

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Hydrochloride Aurobindo (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformine Hydrochloride Aurobindo, is a biguanide presented as an oral tablet for oral use. It is used to lower blood glucose in adults with type 2 diabetes and related metabolic conditions.

GNH India supplies Metformine Hydrochloride Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Metformine Hydrochloride is indicated for disorders of glucose metabolism and related conditions.

  • Type 2 diabetes mellitus: improves glycaemic control by lowering fasting and post‑prandial glucose levels.
  • Prediabetes (impaired fasting glucose): reduces the risk of progression to overt diabetes.
  • Gestational diabetes mellitus: helps achieve target glucose levels when insulin therapy is not required or feasible.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting hepatic gluconeogenesis, thereby decreasing hepatic glucose output. It also reduces intestinal glucose absorption and enhances peripheral insulin sensitivity through activation of AMP‑activated protein kinase (AMPK), leading to improved glucose uptake in muscle and adipose tissue.

Side Effects

Metformine Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or diarrhoea.
  • Metallic taste in the mouth.
  • Mild headache.
  • Decreased appetite.
  • Weight loss (often modest).

Serious or Rare Side Effects

  • Lactic acidosis: a rare but potentially fatal metabolic disturbance.
  • Severe hypoglycaemia (usually when combined with other glucose‑lowering agents).
  • Hepatic dysfunction: elevated liver enzymes.
  • Skin reactions: rash or urticaria.
  • Vitamin B12 deficiency with long‑term use.

Precautions & Warnings

Before initiating Metformine Hydrochloride, several safety considerations should be reviewed.

  • Renal function: assess creatinine clearance; avoid in severe renal impairment.
  • Hepatic disease: use with caution; monitor liver enzymes.
  • Cardiovascular status: consider in patients with heart failure.
  • Alcohol intake: limit, as it may increase risk of lactic acidosis.
  • Pregnancy and lactation: discuss risks and benefits with the prescriber.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformine Hydrochloride can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal failure; discontinue metformin before and after imaging.
  • Cimetidine: can increase metformin plasma concentrations.
  • Certain antiretrovirals (e.g., didanosine): raise risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal clearance of metformin.
  • Beta‑blockers: can mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: monitor renal function when combined.
  • Alcohol: enhances risk of lactic acidosis.

Frequently Asked Questions

Metformine Hydrochloride is a biguanide oral antidiabetic medication used to lower blood glucose in adults with type 2 diabetes, to reduce the risk of progression from prediabetes to diabetes, and in some cases of gestational diabetes when insulin is not required.

Metformin works by inhibiting hepatic glucose production, decreasing intestinal absorption of glucose, and enhancing peripheral insulin sensitivity through activation of the AMP‑activated protein kinase (AMPK) pathway, which together improve overall glycaemic control.

The specific dose and titration schedule are determined by the prescribing clinician based on the patient’s renal function, glycaemic targets, and tolerance. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety in pregnancy and lactation is not fully established. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by the treating physician.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with sulfonylureas, metformin does not cause insulin‑mediated hypoglycaemia and often promotes modest weight loss. Unlike insulin, it is taken orally and does not require injection. It is generally first‑line therapy for type 2 diabetes because of its efficacy, safety profile and low cost.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture, heat and direct sunlight, and keep out of reach of children.

Metformine Hydrochloride is taken orally, usually with meals to minimise gastrointestinal upset. The tablets should be swallowed whole with a glass of water; they are not intended for crushing or dissolving unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or in the setting of acute illness. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Metformine Hydrochloride should be avoided in patients with severe renal impairment (eGFR <30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those who have experienced lactic acidosis while on metformin therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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