Product image of Metformine Zentiva K.S. (Metformin Hydrochloride) supplied by GNH India

Metformine Zentiva K.S.

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metformine Zentiva K.S. (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metformine Zentiva K.S., is a biguanide presented as an oral tablet for oral administration. It reduces hepatic glucose production and improves peripheral insulin sensitivity, providing long‑term glycaemic control for adults with type 2 diabetes mellitus.

GNH India supplies Metformine Zentiva K.S. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU GMP standards and offering reliable logistics for bulk and retail packaging.

Manufacturer / TM Owner

Zentiva France

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Metformine Zentiva K.S. (metformin) is used in the management of disorders related to impaired glucose regulation.

  • Type 2 diabetes mellitus: improves glycaemic control and lowers HbA1c levels.
  • Prediabetes (impaired fasting glucose): delays progression to type 2 diabetes when combined with lifestyle modification.
  • Polycystic ovary syndrome (off‑label): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin Hydrochloride primarily inhibits hepatic gluconeogenesis by activating AMP‑activated protein kinase (AMPK), which reduces glucose output. It also enhances peripheral glucose uptake in muscle and adipose tissue by improving insulin receptor signaling, thereby lowering circulating blood glucose without stimulating insulin secretion.

Side Effects

Metformine Zentiva K.S. may cause a range of adverse reactions.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or dyspepsia.
  • Diarrhea: frequent loose stools, especially during treatment initiation.
  • Metallic taste: transient alteration in taste perception.
  • Loss of appetite: reduced desire to eat.
  • Mild skin rash: occasional pruritic eruptions.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but potentially fatal accumulation of lactate.
  • Severe hypoglycaemia: usually when combined with insulin or secretagogues.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.
  • Pancreatitis: inflammation of the pancreas.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.

Precautions & Warnings

When prescribing Metformine Zentiva K.S., clinicians should consider several safety measures.

  • Renal function assessment: avoid use in patients with severe renal impairment.
  • Hepatic function monitoring: caution in patients with liver disease.
  • Lactic acidosis risk: discontinue if signs of metabolic acidosis appear.
  • Elderly patients: start at lower doses and monitor tolerance.
  • Alcohol consumption: advise limiting intake to reduce acidosis risk.
  • Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture.

Avoid Interactions

Metformine Zentiva K.S. interacts with several medicines that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: can precipitate acute renal failure and lactic acidosis.
  • Cimetidine: may increase metformin plasma concentrations.
  • Alcohol: potentiates risk of lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • ACE inhibitors or ARBs: can affect renal function, requiring dose adjustment.
  • Thiazide diuretics: may increase risk of hypoglycaemia.

Frequently Asked Questions

Metformine Zentiva K.S. contains metformin hydrochloride and is indicated for the treatment of type 2 diabetes mellitus. It helps lower elevated blood glucose levels by improving the body’s response to insulin and reducing glucose production in the liver.

Metformin Hydrochloride activates AMP‑activated protein kinase (AMPK), which suppresses hepatic gluconeogenesis and enhances peripheral glucose uptake. By doing so, it lowers fasting and post‑prandial blood glucose without directly stimulating insulin secretion.

The appropriate dose of Metformine Zentiva K.S. is individualized by the prescribing healthcare professional based on the patient’s glycaemic targets, renal function, age, and tolerance. Dosage adjustments are made according to clinical response and safety monitoring.

The safety of Metformine Zentiva K.S. in pregnancy and lactation has not been definitively established. Physicians should weigh potential benefits against possible risks and discuss alternative options with pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformine Zentiva K.S. belongs to the biguanide class, which improves insulin sensitivity without causing hypoglycaemia when used alone. Compared with sulfonylureas, it does not stimulate insulin release, and unlike insulin therapy, it is administered orally and has a lower risk of weight gain.

Store Metformine Zentiva K.S. at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed.

Metformine Zentiva K.S. is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a full glass of water; it is not intended for crushing, chewing, or dissolving.

The most critical safety concerns are lactic acidosis—a rare but life‑threatening condition—and severe hypoglycaemia when combined with insulin or secretagogues. Patients should seek immediate medical attention for symptoms such as unexplained muscle pain, rapid breathing, abdominal discomfort, or marked fatigue.

Metformine Zentiva K.S. is contraindicated in individuals with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, and in patients with severe hepatic disease. Caution is also advised for the elderly and those with unstable heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Metformin Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT