Product image of Metforminhydrochlorid Al (Metformin Hydrochloride) supplied by GNH India

Metforminhydrochlorid Al

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Metforminhydrochlorid Al (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Metforminhydrochlorid Al, is a biguanide presented as an oral tablet for oral use. It is indicated for the management of type 2 diabetes mellitus in adults and is commonly prescribed as part of a comprehensive glucose‑lowering regimen.

GNH India supplies Metforminhydrochlorid Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Metformin Hydrochloride is a biguanide that lowers blood glucose by targeting hepatic glucose production and insulin sensitivity.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Prediabetes (impaired glucose tolerance): helps delay progression to overt diabetes when used with lifestyle measures.
  • Polycystic ovary syndrome (off‑label): may improve insulin resistance and menstrual regularity.

How It Works

  • Metformin Hydrochloride primarily inhibits mitochondrial respiratory-chain complex I, reducing hepatic gluconeogenesis. It also increases peripheral insulin sensitivity by enhancing glucose uptake in muscle and adipose tissue and modestly decreases intestinal glucose absorption, collectively lowering fasting and post‑prandial blood glucose levels without stimulating insulin secretion.

Side Effects

Metformin Hydrochloride may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort, or loss of appetite.
  • Diarrhea: often mild to moderate and transient.
  • Metallic taste: a transient alteration in taste perception.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: may develop with long‑term use.
  • Flatulence: increased intestinal gas.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic complication.
  • Severe hypoglycemia: typically when combined with other glucose‑lowering agents.
  • Hepatic failure: rare cases of liver injury.
  • Allergic skin reactions: rash, pruritus, or urticaria.
  • Neutropenia: reduced white blood cell count.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

When prescribing Metformin, clinicians should consider several precautionary measures to minimize risk.

  • Renal function: assess eGFR before initiation and periodically thereafter.
  • Hepatic function: evaluate liver disease prior to use.
  • Age: start at lower dose in elderly patients.
  • Alcohol consumption: advise patients to limit intake.
  • Concomitant medications: review for drugs that may increase risk of lactic acidosis.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Metformin may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: risk of acute renal failure and lactic acidosis.
  • Cimetidine: may increase metformin plasma concentrations.
  • Alcohol: potentiates risk of lactic acidosis.
  • Beta‑blockers: can mask hypoglycemia symptoms.
  • Diuretics (loop, thiazide): may impair renal clearance.

Moderate Interactions (Monitor Closely)

  • Sulfonylureas: increased risk of hypoglycemia.
  • DPP‑4 inhibitors: additive glucose‑lowering effect.
  • ACE inhibitors/ARBs: monitor renal function.
  • Thyroid hormones: may affect glycemic control.
  • Antibiotics (e.g., fluoroquinolones): watch for renal function changes.

Frequently Asked Questions

Metforminhydrochlorid Al contains Metformin Hydrochloride, which is used to improve blood‑sugar control in adults with type 2 diabetes mellitus. It is part of a comprehensive treatment plan that may include diet, exercise, and other glucose‑lowering agents.

Metformin works by inhibiting hepatic gluconeogenesis, increasing insulin sensitivity in muscle and fat tissues, and reducing intestinal glucose absorption. These actions lower both fasting and post‑prandial blood glucose levels without directly stimulating insulin secretion.

The appropriate dose of Metforminhydrochlorid Al is determined by the prescribing healthcare professional based on the individual’s renal function, glycemic targets, and overall treatment plan. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Metforminhydrochlorid Al in pregnancy and lactation is not fully established. Healthcare providers should weigh potential benefits against possible risks and discuss options with the patient. Breastfeeding mothers should consult their clinician before using the product.

To order Metforminhydrochlorid Al, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metformin is a first‑line biguanide that improves insulin sensitivity and reduces hepatic glucose output, whereas sulfonylureas stimulate insulin release, and SGLT2 inhibitors increase urinary glucose excretion. Metformin generally has a lower risk of hypoglycemia and is weight‑neutral or modestly weight‑reducing, making it a preferred initial therapy for many patients.

Store Metforminhydrochlorid Al at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Metforminhydrochlorid Al is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablets should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with significant renal impairment, hepatic disease, or excessive alcohol intake. Prompt medical attention is required if symptoms such as unexplained muscle pain, rapid breathing, or abdominal discomfort develop.

Metforminhydrochlorid Al is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis, known hypersensitivity to metformin, or those receiving iodinated contrast studies without adequate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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