Product image of Metgen (Metoclopramide Hydrochloride Anhydrous) supplied by GNH India

Metgen

Active Ingredient:
Metoclopramide Hydrochloride Anhydrous
Origin:
EU

Metgen (Metoclopramide Hydrochloride Anhydrous)

Metoclopramide, the active ingredient in Metgen, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It is employed to relieve nausea, vomiting, and to improve gastrointestinal motility in several clinical situations.

GNH India supplies Metgen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metgen acts on the dopamine pathways that trigger nausea and on gastrointestinal motility, making it useful for several digestive and post‑surgical conditions.

  • Nausea and vomiting: reduces episodes by blocking dopamine receptors in the chemoreceptor trigger zone.
  • Gastroparesis: enhances gastric emptying through increased acetylcholine release.
  • Gastro‑oesophageal reflux disease (GERD): improves lower‑esophageal sphincter tone and accelerates gastric clearance.
  • Post‑operative nausea: prevents nausea after surgical procedures by central anti‑emetic action.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the central vomiting stimulus. Concurrently, it blocks presynaptic dopamine receptors in the gastrointestinal tract, which leads to increased acetylcholine release, thereby stimulating smooth‑muscle contraction and accelerating gastric emptying.

Side Effects

Metgen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dry mouth: reduced salivation leading to a parched sensation.
  • Constipation: slowed bowel movements.
  • Restlessness or akathisia: an inner feeling of unease.
  • Dizziness: light‑headed sensation, especially when standing.
  • Fatigue: general lack of energy.

Serious or Rare Side Effects

  • Tardive dyskinesia: involuntary, repetitive movements, potentially irreversible.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Severe depression or suicidal thoughts.
  • Seizures: convulsive episodes.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

When prescribing Metgen, clinicians should consider several safety aspects.

  • Assess renal function: dose adjustment may be needed in impaired kidneys.
  • Monitor for extrapyramidal symptoms: watch for muscle rigidity or tremor.
  • Avoid in patients with known hypersensitivity to metoclopramide.
  • Use caution in the elderly: increased susceptibility to CNS effects.
  • Pregnancy and lactation: safety not established; weigh benefits against risks.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metgen can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may raise metoclopramide plasma levels.
  • MAO inhibitors: risk of hypertensive crisis when combined.
  • Anticholinergic agents: additive anticholinergic burden can worsen constipation and dry mouth.

Moderate Interactions (Monitor Closely)

  • Opioids: combined CNS depression may increase sedation.
  • Other dopamine antagonists: heightened risk of extrapyramidal reactions.
  • Alcohol: may enhance drowsiness and dizziness.

Frequently Asked Questions

Metgen, containing metoclopramide, is prescribed for nausea and vomiting, gastroparesis, gastro‑oesophageal reflux disease, and post‑operative nausea. It works by blocking dopamine receptors that trigger vomiting and by stimulating gastrointestinal motility to aid digestion.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the urge to vomit. In the gut, it blocks presynaptic dopamine receptors, which increases acetylcholine release, leading to stronger smooth‑muscle contractions and faster gastric emptying.

The dosage of Metgen is determined by the prescribing clinician based on the patient’s condition, age, renal function, and response to therapy. Healthcare professionals set the appropriate strength, frequency, and duration for each individual case.

Safety data for metoclopramide in pregnancy and lactation are limited, and the product’s pregnancy category is unknown. Clinicians should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing patients.

To request Metgen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metgen (metoclopramide) differs from many anti‑emetics such as ondansetron, which primarily blocks serotonin receptors. Metoclopramide’s dopamine antagonism and pro‑kinetic activity make it useful for both nausea control and gastric motility, whereas agents like ondansetron lack the pro‑kinetic effect.

Metgen should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metgen is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact timing and whether it should be taken before, during, or after meals depends on the specific indication and the clinician’s recommendation.

Serious risks include tardive dyskinesia, a potentially irreversible movement disorder, neuroleptic malignant syndrome, severe depression or suicidal thoughts, seizures, and allergic reactions such as anaphylaxis. Patients should be monitored closely for any of these symptoms.

Metgen is contraindicated in individuals with known hypersensitivity to metoclopramide, those with pheochromocytoma, and patients taking monoamine oxidase inhibitors (MAOIs). Caution is also advised for patients with severe renal impairment, epilepsy, or a history of extrapyramidal disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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