Product image of Metgen (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metgen

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metgen (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide, the active ingredient in Metgen, is a dopamine antagonist (antiemetic) presented as an oral tablet for oral use. It is employed to relieve nausea and vomiting, improve gastric emptying in gastroparesis, and manage reflux esophagitis and chemotherapy‑induced nausea.

GNH India supplies Metgen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established quality‑assured manufacturing, regulatory approvals across the EU, and a dedicated logistics network for timely delivery. The company also provides technical support and documentation to meet local regulatory requirements.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metoclopramide is used to treat disorders of the gastrointestinal tract and the central emetic pathways.

  • Nausea and vomiting: reduces episodes by blocking dopamine receptors in the chemoreceptor trigger zone.
  • Gastroparesis: enhances gastric motility and accelerates emptying to improve symptoms.
  • Reflux esophagitis: increases lower esophageal sphincter tone and promotes gastric clearance, reducing reflux episodes.
  • Chemotherapy‑induced nausea: prevents or lessens nausea associated with cytotoxic agents by antagonizing central dopamine pathways.

How It Works

  • Metoclopramide acts as a competitive antagonist at dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract. By blocking these receptors, it diminishes the central vomiting stimulus and stimulates cholinergic pathways, which enhances upper gastrointestinal motility, promotes coordinated peristalsis, and accelerates gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness or anxiety: mild agitation or nervousness.
  • Diarrhea: loose or frequent stools.
  • Dry mouth: reduced salivation causing discomfort.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or involuntary movements.
  • Tardive dyskinesia: persistent, potentially irreversible facial or limb movements.
  • Neuroleptic malignant syndrome: rare but life‑threatening hyperthermia and muscle breakdown.
  • Severe depression or suicidal thoughts.
  • Cardiac arrhythmias: irregular heart rhythm, especially in patients with underlying heart disease.

Precautions & Warnings

Before prescribing Metgen, clinicians should consider several safety measures.

  • Assess patient history: screen for Parkinson's disease, seizure disorders, or depression.
  • Monitor for extrapyramidal symptoms: observe for muscle rigidity, tremor, or involuntary movements.
  • Limit duration: avoid use beyond 12 days unless medically justified.
  • Avoid in children under 1 year: contraindicated due to risk of severe side effects.
  • Pregnancy and lactation: use only if benefit outweighs risk; data are limited.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increase metoclopramide plasma concentrations.
  • Anticholinergic agents: may reduce the prokinetic effect of metoclopramide.
  • Other dopamine antagonists (e.g., antipsychotics): additive risk of extrapyramidal symptoms.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, alcohol): enhance sedation and drowsiness.
  • Macrolide antibiotics (e.g., erythromycin): may increase gastrointestinal motility synergistically.
  • Serotonergic agents (e.g., SSRIs): potential for serotonin syndrome when combined with other antiemetics.

Frequently Asked Questions

Metgen, containing metoclopramide, is prescribed for nausea and vomiting of various origins, gastroparesis, reflux esophagitis, and for preventing nausea associated with chemotherapy. It works by enhancing stomach emptying and blocking central dopamine receptors that trigger vomiting.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the vomiting signal. It also stimulates cholinergic pathways in the gastrointestinal tract, increasing motility and accelerating gastric emptying, which helps relieve reflux and gastroparesis symptoms.

The dosage of Metgen is determined by the prescribing clinician based on the patient’s condition, age, renal function, and response to therapy. Physicians tailor the regimen to achieve optimal symptom control while minimizing potential side effects.

Safety data for metoclopramide in pregnancy and lactation are limited. It should be used only when the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Metgen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metgen (metoclopramide) differs from other antiemetics such as ondansetron, which primarily blocks serotonin receptors. Metoclopramide’s dopamine antagonism provides both anti‑nausea and pro‑kinetic effects, making it useful for conditions involving delayed gastric emptying, whereas serotonin antagonists lack this motility benefit.

Metgen should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Metgen is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless a healthcare provider advises an alternative method based on the patient’s specific needs.

Serious risks include extrapyramidal reactions such as muscle rigidity or tremor, tardive dyskinesia, neuroleptic malignant syndrome, severe depression, and cardiac arrhythmias. Patients should be monitored closely for these events, especially during prolonged therapy.

Metgen is contraindicated in patients with known hypersensitivity to metoclopramide, those with pheochromocytoma, and children younger than one year. Caution is also advised for individuals with Parkinson’s disease, seizure disorders, or severe depression, and it should be avoided in pregnancy unless clearly needed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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