Product image of Methadon Hcl Teva (Methadone Hydrochloride) supplied by GNH India

Methadon Hcl Teva

Active Ingredient:
Methadone Hydrochloride
Origin:
EU

Methadon Hcl Teva (Methadone Hydrochloride)

Methadone Hydrochloride, the active ingredient in Methadon Hcl Teva, is a synthetic opioid presented as an oral formulation for oral use. It is employed in the management of opioid dependence and chronic pain, primarily in adult patients who require long‑term opioid therapy.

GNH India supplies Methadon Hcl Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Methadone Hydrochloride is used within the opioid dependence and pain‑management pathways to provide controlled opioid agonism.

  • Opioid dependence: stabilises patients by reducing withdrawal symptoms and cravings.
  • Opioid use disorder: supports maintenance therapy to prevent relapse.
  • Chronic pain: offers long‑acting analgesia for patients with severe, persistent pain unresponsive to non‑opioid options.

How It Works

  • Methadone Hydrochloride acts as a full agonist at the mu‑opioid receptor, producing analgesia and suppressing withdrawal by mimicking endogenous opioids. It also exhibits NMDA receptor antagonism and inhibits serotonin and norepinephrine reuptake, contributing to its efficacy in chronic pain and opioid substitution therapy.

Side Effects

Methadone Hydrochloride may cause a range of adverse reactions, from mild to life‑threatening.

Common Side Effects

  • Nausea or vomiting
  • Constipation
  • Drowsiness or sedation
  • Sweating
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Respiratory depression
  • QT interval prolongation leading to arrhythmia
  • Severe hypotension
  • Adrenal insufficiency
  • Seizures
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

When prescribing Methadone Hydrochloride, clinicians should observe several safety measures.

  • Respiratory monitoring: assess breathing function, especially during initiation or dose changes.
  • Cardiac assessment: obtain baseline ECG and monitor QT interval.
  • Liver function: evaluate hepatic status before and during therapy.
  • Renal impairment: adjust dosing and monitor for accumulation.
  • Discontinuation: taper gradually to avoid precipitated withdrawal.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Methadone Hydrochloride interacts with several drug classes that can alter its safety or efficacy.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, barbiturates): risk of profound respiratory depression.
  • MAO inhibitors: can cause severe hypertension or serotonin syndrome.
  • QT‑prolonging agents (e.g., certain antiarrhythmics, antipsychotics): increase risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin, ketoconazole): may raise methadone plasma levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Anticholinergic drugs: can exacerbate constipation.
  • Alcohol: additive CNS depression.
  • Herbal supplements (e.g., St. John’s wort): may affect metabolism.

Frequently Asked Questions

Methadon Hcl Teva, containing methadone hydrochloride, is indicated for the treatment of opioid dependence and opioid use disorder, as well as for the management of chronic, severe pain that requires long‑term opioid therapy. It helps reduce withdrawal symptoms, cravings, and provides sustained analgesia.

Methadone hydrochloride binds to mu‑opioid receptors, acting as a full agonist to produce analgesia and suppress withdrawal. Its additional NMDA receptor antagonism and inhibition of serotonin and norepinephrine reuptake contribute to pain relief and may reduce tolerance development.

The specific dose of Methadon Hcl Teva is individualized by the prescribing clinician based on the patient’s medical condition, prior opioid exposure, and response to therapy. Dosing is titrated carefully to achieve therapeutic effect while minimizing adverse reactions.

Safety data for methadone hydrochloride in pregnancy and lactation are limited. It may be used when the potential benefit justifies the potential risk to the fetus or infant. Clinicians should weigh risks and discuss them with the patient; breastfeeding decisions should follow local guidelines.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Methadon Hcl Teva offers a long‑acting oral option with additional NMDA antagonism, which may reduce tolerance compared with shorter‑acting opioids. Compared with buprenorphine, methadone provides full mu‑opioid agonism, which can be advantageous for patients with high opioid tolerance, but it requires more intensive monitoring.

Store Methadon Hcl Teva at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and extreme heat to maintain stability and potency.

Methadon Hcl Teva is administered orally, typically as a tablet or liquid taken with water. The exact route (swallow whole or dissolve) follows the prescriber’s instructions and the specific dosage form supplied.

The most serious risks include respiratory depression, especially during dose escalation or when combined with other CNS depressants, and QT interval prolongation that can lead to life‑threatening arrhythmias. Regular monitoring of breathing, cardiac rhythm, and plasma levels helps mitigate these risks.

Methadon Hcl Teva should be avoided in patients with known hypersensitivity to methadone, severe respiratory insufficiency, uncontrolled cardiac arrhythmias, or those taking contraindicated medications such as MAO inhibitors. Caution is also advised for individuals with significant hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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