Methadone Macarthys Laboratories (Methadone Hydrochloride)

Methadone works by acting as a full agonist at the µ‑opioid receptors, which produces analgesic effects and mitigates opioid withdrawal. Additionally, it blocks NMDA receptors, a property that may help limit the development of tolerance and provide benefit in certain neuropathic pain conditions.

The appropriate dose of methadone injection is individualized and must be determined by a qualified prescriber. Dosing depends on factors such as the patient’s opioid tolerance, the severity of pain or dependence, renal and hepatic function, and concurrent medications.

Methadone is classified as pregnancy category unknown, and limited data are available on its safety in pregnancy and lactation. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with obstetric and neonatal specialists.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Both methadone and buprenorphine are used for opioid substitution, but methadone is a full µ‑opioid agonist providing more consistent analgesia, whereas buprenorphine is a partial agonist with a ceiling effect on respiratory depression. Methadone generally requires daily dosing and careful monitoring of cardiac effects, while buprenorphine offers a lower risk of overdose but may be less effective for severe pain.

Methadone injection should be stored at controlled room temperature, protected from light and moisture, and kept in its original packaging. Do not freeze the product, and ensure that the vial is sealed when not in use to maintain sterility.

Methadone injection is administered by a qualified healthcare professional via the intramuscular or subcutaneous route. The injection site should be rotated as needed, and the volume administered should not exceed the recommended limits for the chosen route to avoid local irritation.

The most serious risks include respiratory depression, which can be life‑threatening, and cardiac arrhythmias due to QT interval prolongation. Patients should be monitored closely for signs of shallow breathing, excessive sedation, or irregular heart rhythms, especially after dose adjustments or when interacting drugs are introduced.

Methadone injection is contraindicated in individuals with known hypersensitivity to methadone or any component of the formulation, in patients with acute intoxication from alcohol, benzodiazepines or other central nervous system depressants, and in those with uncorrected severe cardiac conduction abnormalities that predispose to QT prolongation.