Product image of Methergin (Methylergometrine Maleate) supplied by GNH India

Methergin

Active Ingredient:
Methylergometrine Maleate
Origin:
EU

Methergin (Methylergometrine Maleate)

Methylergometrine maleate, the active ingredient in Methergin, is an ergot alkaloid presented as an injectable solution for intramuscular and intravenous use. It is used to prevent and treat postpartum hemorrhage and uterine atony in women after delivery.

GNH India supplies Methergin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Methylergometrine maleate is an ergot alkaloid uterotonic used to manage uterine bleeding.

  • Postpartum hemorrhage: helps control excessive bleeding by stimulating strong uterine contractions.
  • Uterine atony: restores tone to a relaxed uterus following childbirth.
  • Prophylaxis of postpartum hemorrhage: administered after delivery to reduce the risk of severe bleeding.

How It Works

  • Methylergometrine maleate acts as a partial agonist at serotonin (5‑HT2), alpha‑adrenergic and dopaminergic receptors in uterine smooth muscle, producing sustained contraction and reducing uterine blood flow, which assists in controlling postpartum hemorrhage.

Side Effects

Methylergometrine maleate may cause a range of adverse reactions.

Common Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Hypertension
  • Abdominal pain
  • Flushing

Serious or Rare Side Effects

  • Coronary artery spasm or myocardial infarction
  • Severe hypertension or hypertensive crisis
  • Seizures
  • Allergic reactions including anaphylaxis
  • Uterine rupture
  • Peripheral ischemia

Precautions & Warnings

Methylergometrine maleate requires careful clinical assessment before use.

  • Contraindication in pregnancy: not to be used before delivery due to fetal toxicity.
  • Hypertension: monitor blood pressure closely as the drug can raise systemic pressure.
  • Cardiovascular disease: avoid in patients with coronary artery disease or severe vascular disorders.
  • Asthma: use with caution because bronchospasm may occur.
  • Drug hypersensitivity: discontinue immediately if an allergic reaction is observed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methylergometrine maleate can interact with several medication classes.

Major Interactions (Avoid)

  • Other ergot derivatives: additive vasoconstriction risk.
  • MAO inhibitors: may precipitate hypertensive crisis.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase plasma concentrations.
  • Concomitant vasopressors (e.g., norepinephrine): severe hypertension.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance uterine contractile effect.
  • SSRIs or other serotonergic agents: potential serotonin syndrome.
  • Lithium: increased risk of toxicity.

Frequently Asked Questions

Methergin contains methylergometrine maleate, an ergot alkaloid uterotonic that is used to prevent and treat postpartum hemorrhage and to manage uterine atony after childbirth.

The drug acts as a partial agonist at serotonin (5‑HT2), alpha‑adrenergic and dopaminergic receptors in uterine smooth muscle, causing sustained contraction and reduced uterine blood flow, which helps control bleeding.

The dose of Methergin is determined by the prescribing clinician based on the patient’s condition, route of administration and clinical guidelines. Specific dosing regimens are not provided here.

Methergin is classified as pregnancy category X, indicating it should not be used during pregnancy because of fetal risk. Use after delivery is appropriate, but it is not recommended for breastfeeding mothers without medical supervision.

To order Methergin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Methergin belongs to the ergot alkaloid class, whereas alternatives such as oxytocin are peptide hormones. Ergot alkaloids produce longer‑lasting uterine contraction but carry a higher risk of vasoconstrictive side effects, making patient selection important.

Methergin should be stored at 2‑8 °C, kept refrigerated, protected from light, and not frozen or shaken. Maintaining the cold chain preserves its stability and efficacy.

Methergin is supplied as an injectable solution and can be given either intramuscularly or intravenously by a qualified healthcare professional, following aseptic technique and appropriate dosing guidelines.

Serious risks include severe hypertension, coronary artery spasm, myocardial infarction, uterine rupture, seizures and life‑threatening allergic reactions. Prompt recognition and medical intervention are essential if these events occur.

Methergin should not be used in pregnant women before delivery, patients with known hypersensitivity to ergot alkaloids, those with uncontrolled hypertension, significant cardiovascular disease, severe asthma, or any condition where vasoconstriction could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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