Product image of Methofill (Methotrexate) supplied by GNH India

Methofill

Active Ingredient:
Methotrexate
Origin:
EU

Methofill (Methotrexate)

Methotrexate, the active ingredient in Methofill, is an Antimetabolite presented as a subcutaneous injection for Subcutaneous use. It is used to treat autoimmune disorders such as rheumatoid arthritis and psoriasis, as well as certain cancers, in adult patients.

GNH India supplies Methofill as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methofill acts on rapidly dividing cells and immune pathways, making it useful across several disease families.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin cell proliferation and plaque formation.
  • Psoriatic arthritis: alleviates joint pain and skin symptoms.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication.
  • Other malignancies: used as part of combination chemotherapy regimens.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, leading to reduced tetrahydrofolate production. This blocks purine and pyrimidine synthesis, impairing DNA replication and cell division. The resulting suppression of rapidly proliferating immune cells and malignant cells underlies its therapeutic effects in autoimmune diseases and cancer.

Side Effects

Methofill may cause a range of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Nausea or vomiting: gastrointestinal upset is frequently reported.
  • Fatigue: patients often experience reduced energy levels.
  • Mouth sores: ulceration of oral mucosa may occur.
  • Elevated liver enzymes: mild hepatic irritation is common.

Serious or Rare Side Effects

  • Bone marrow suppression: can lead to anemia, leukopenia, or thrombocytopenia.
  • Pulmonary toxicity: interstitial pneumonitis may develop.
  • Severe hepatic injury: rare cases of liver fibrosis or cirrhosis.
  • Renal impairment: reduced kidney function can occur.
  • Cutaneous reactions: severe skin rashes or Stevens‑Johnson syndrome.

Precautions & Warnings

Methofill requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated (Category X); avoid use in pregnant or trying-to-conceive patients.
  • Renal function: assess baseline kidney function and adjust if impairment is present.
  • Hepatic function: monitor liver enzymes regularly during therapy.
  • Blood counts: perform complete blood count before initiation and periodically thereafter.
  • Drug interactions: review concomitant medications for potential additive toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Methofill can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of renal toxicity.
  • Proton pump inhibitors: may elevate methotrexate serum levels.
  • Trimethoprim‑sulfamethoxazole: potentiates bone marrow suppression.

Moderate Interactions (Monitor Closely)

  • Penicillins: may reduce renal clearance of methotrexate.
  • Sulfonamides: can enhance hematologic toxicity.
  • Live vaccines: immunosuppression may diminish vaccine efficacy.

Frequently Asked Questions

Methofill contains methotrexate and is prescribed for several immune‑mediated and oncologic conditions, including rheumatoid arthritis, psoriasis, psoriatic arthritis, acute lymphoblastic leukemia, and other selected malignancies where inhibition of cell proliferation is required.

Methotrexate blocks dihydrofolate reductase, reducing tetrahydrofolate levels needed for DNA synthesis. This limits the growth of rapidly dividing cells, suppresses immune cell proliferation, and thereby reduces inflammation in autoimmune diseases and impedes cancer cell replication.

The specific dose of Methofill is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and treatment goals. Dosage regimens are individualized and should follow the prescriber’s instructions.

Methofill is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. It is also not recommended while breastfeeding because it can be excreted in milk and affect the infant.

To request Methofill, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Methofill (methotrexate) is a first‑line conventional DMARD with a well‑established efficacy and safety profile. Compared with biologic DMARDs, it is generally less expensive and administered subcutaneously, but may require more frequent monitoring for hepatic, renal and hematologic effects.

Methofill should be stored at 2‑8 °C (refrigerated). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial to maintain stability.

Methofill is given as a subcutaneous injection. The injection is typically performed by a healthcare professional or trained patient using a pre‑filled syringe or autoinjector, following aseptic technique and the prescriber’s dosing schedule.

The most serious risks include bone‑marrow suppression leading to severe anemia or infection, pulmonary toxicity such as interstitial pneumonitis, significant liver injury, and renal failure. Prompt monitoring of blood counts, liver and kidney function is essential to detect these complications early.

Methofill is contraindicated in pregnant women, patients with severe renal or hepatic impairment, those with known hypersensitivity to methotrexate, and individuals receiving live vaccines. It should also be used with caution in patients with pre‑existing blood dyscrasias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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