Product image of Methotrexaat Teva (Methotrexate) supplied by GNH India

Methotrexaat Teva

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexaat Teva (Methotrexate)

Methotrexate, the active ingredient in Methotrexaat Teva, is an antimetabolite (folate antagonist) presented as an oral tablet for oral use. It treats rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and other malignancies responsive to antimetabolite therapy.

GNH India supplies Methotrexaat Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Methotrexate is used in autoimmune and oncologic disease pathways to modulate cell proliferation and immune activity.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin cell turnover and plaque formation.
  • Acute lymphoblastic leukemia: interferes with malignant lymphoblast replication.
  • Non‑Hodgkin lymphoma: impedes growth of lymphoma cells.
  • Other malignancies responsive to antimetabolite therapy: provides cytotoxic effects against rapidly dividing tumor cells.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the availability of tetrahydrofolate, a cofactor required for synthesis of purine nucleotides and thymidylate, thereby disrupting DNA, RNA and protein synthesis in rapidly dividing cells and modulating immune cell activity.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting
  • Mucositis or mouth sores
  • Fatigue or weakness
  • Alopecia (hair loss)
  • Elevated liver enzymes
  • Mild skin rash

Serious or Rare Side Effects

  • Bone marrow suppression leading to pancytopenia
  • Severe hepatic toxicity or fibrosis
  • Pulmonary fibrosis or interstitial pneumonitis
  • Life‑threatening infections due to immunosuppression
  • Renal impairment or failure
  • Severe cutaneous reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

  • Before initiating therapy, several safety considerations should be addressed.
  • Monitor blood counts: perform regular complete blood count assessments.
  • Assess liver function: check hepatic enzymes periodically.
  • Evaluate renal function: adjust dosing if creatinine clearance is reduced.
  • Avoid in pregnancy: teratogenic risk requires effective contraception.
  • Review concomitant nephrotoxic or hepatotoxic drugs: adjust or discontinue as needed.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its efficacy or toxicity.

Major Interactions (Avoid)

  • NSAIDs: increase methotrexate plasma levels and risk of toxicity.
  • Trimethoprim‑sulfamethoxazole: potentiate myelosuppression.
  • Live vaccines: may cause uncontrolled infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may affect renal clearance.
  • Penicillins and other β‑lactam antibiotics: modestly increase toxicity risk.
  • Alcohol: can exacerbate hepatic injury.

Frequently Asked Questions

Methotrexaat Teva contains methotrexate, which is prescribed for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and other cancers that respond to antimetabolite therapy. It works by reducing inflammation in autoimmune diseases and by inhibiting the growth of malignant cells.

Methotrexate blocks the enzyme dihydrofolate reductase, limiting the production of tetrahydrofolate. This shortage hampers the synthesis of DNA, RNA and proteins, which are essential for rapidly dividing cells. The result is reduced proliferation of immune cells in arthritis and slowed growth of cancer cells.

The specific dose of Methotrexaat Teva is determined by the prescribing clinician based on the patient’s condition, weight, renal function and treatment goals. Only a qualified healthcare professional should set the dosing regimen.

Methotrexaat Teva is classified as pregnancy category X because it can cause severe fetal malformations and miscarriage. It is contraindicated in pregnancy and women of childbearing potential must use effective contraception. Breastfeeding is also not recommended as the drug is excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Methotrexaat Teva (methotrexate) is a folate antagonist, whereas other antimetabolites such as 5‑fluorouracil or cytarabine target different enzymes in nucleotide synthesis. Methotrexate is widely used for both autoimmune disorders and several cancers, offering a broader therapeutic scope but also requiring careful monitoring of liver and marrow function.

Methotrexaat Teva should be stored at temperatures below 25 °C in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain stability and potency throughout its shelf life.

Methotrexaat Teva is supplied as oral tablets that are taken by mouth with water. The prescribing physician will advise whether the tablet should be taken with food or on an empty stomach, and will schedule the dosing frequency appropriate for the indication.

The most serious risks include bone marrow suppression leading to severe infections or bleeding, significant liver toxicity that can progress to fibrosis, and pulmonary complications such as interstitial pneumonitis. Patients should be monitored regularly for blood counts, liver enzymes and respiratory symptoms.

Methotrexaat Teva is contraindicated in pregnant women, individuals with severe renal or hepatic impairment, patients with known hypersensitivity to methotrexate, and those receiving live vaccines. It should also be avoided in patients with active infections that could be worsened by immunosuppression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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