Product image of Methotrexat Accord (Methotrexate) supplied by GNH India

Methotrexat Accord

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexat Accord (Methotrexate)

Methotrexate, the active ingredient in Methotrexat Accord, is an antimetabolite presented as a sterile injectable for intraarterial, intramuscular, intrathecal use. It treats several autoimmune and oncologic conditions in adults and children as prescribed by a physician.

GNH India supplies Methotrexat Accord as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methotrexate is an antimetabolite used in autoimmune and oncologic disease pathways.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin cell proliferation and improves plaque severity.
  • Acute lymphoblastic leukemia: interferes with malignant lymphoblast replication.
  • Osteosarcoma: limits tumor growth by inhibiting DNA synthesis.
  • Gestational trophoblastic disease: promotes resolution of abnormal trophoblastic tissue.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the availability of reduced folate cofactors required for thymidylate and purine synthesis, leading to impaired DNA, RNA, and protein production. The resulting inhibition of cell proliferation affects rapidly dividing immune cells and malignant tumor cells, providing its therapeutic effects in autoimmune disorders and cancers.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue or weakness.
  • Mucositis or mouth sores.
  • Alopecia (hair loss).
  • Elevated liver enzymes.
  • Mild skin rash.

Serious or Rare Side Effects

  • Bone marrow suppression leading to pancytopenia.
  • Severe hepatotoxicity or fibrosis.
  • Pulmonary toxicity, including interstitial pneumonitis.
  • Life‑threatening infections due to immunosuppression.
  • Acute renal failure.
  • Anaphylactic or severe hypersensitivity reactions.

Precautions & Warnings

When using Methotrexat Accord, several safety measures should be observed.

  • Monitor liver function: perform baseline and periodic liver enzyme tests.
  • Monitor blood counts: check complete blood count regularly to detect myelosuppression.
  • Avoid use in pregnancy: contraindicated (Category X) and requires effective contraception.
  • Adjust dose in renal impairment: assess renal function before initiation and during therapy.
  • Limit alcohol consumption: reduces additional hepatic stress.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its safety or efficacy.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Trimethoprim‑sulfamethoxazole: potentiates myelosuppression.
  • Live vaccines: risk of severe infection.
  • Phenytoin and other enzyme‑inducing anticonvulsants: reduce methotrexate levels.
  • High‑dose folic acid supplements: may diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Proton‑pump inhibitors: may affect renal clearance.
  • ACE inhibitors or angiotensin‑II blockers: increase risk of renal dysfunction.
  • Alcohol: adds hepatic burden.
  • Antacids containing aluminum or magnesium: can affect absorption.
  • Sulfonylureas: may enhance hypoglycaemia risk.

Frequently Asked Questions

Methotrexat Accord contains methotrexate, an antimetabolite indicated for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, osteosarcoma, and gestational trophoblastic disease. It is prescribed by a qualified healthcare professional to manage autoimmune inflammation and to inhibit the growth of certain cancer cells.

Methotrexate blocks the enzyme dihydrofolate reductase, which is essential for converting dihydrofolate to tetrahydrofolate. This inhibition reduces the supply of folate needed for DNA, RNA, and protein synthesis, thereby limiting the proliferation of rapidly dividing cells such as immune cells and malignant tumor cells.

The specific dose of Methotrexat Accord is individualized by the prescribing clinician based on the patient’s condition, age, weight, renal and hepatic function, and treatment goals. Only a qualified healthcare provider can determine the appropriate dosage regimen.

Methotrexat Accord is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended during breastfeeding, as it may be excreted in milk and affect the infant. Effective contraception is required for women of childbearing potential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Methotrexat Accord (methotrexate) is a first‑line antimetabolite widely used for both autoimmune diseases and certain cancers. Compared with newer agents such as leflunomide or biologics, methotrexate is less expensive but requires careful monitoring for toxicity. Its broad indication profile makes it a versatile option when cost and efficacy balance are priorities.

Methotrexat Accord should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not freeze the product, and keep it out of reach of children.

Methotrexat Accord is supplied as a sterile injectable solution and may be given via intra‑arterial, intramuscular, or intrathecal routes, depending on the indication and clinical protocol. Administration is performed by a qualified healthcare professional under aseptic conditions.

The most serious risks include bone marrow suppression leading to severe pancytopenia, hepatotoxicity that can progress to fibrosis or cirrhosis, pulmonary toxicity such as interstitial pneumonitis, and life‑threatening infections due to immunosuppression. Patients should be monitored closely for signs of these complications.

Methotrexat Accord is contraindicated in pregnant women, individuals with severe liver disease, uncontrolled infections, and those with known hypersensitivity to methotrexate or any component of the formulation. Caution is also advised for patients with significant renal impairment or existing bone marrow disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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