Product image of Methotrexat Accord (Methotrexate) supplied by GNH India

Methotrexat Accord

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexat Accord (Methotrexate)

Methotrexate, the active ingredient in Methotrexat Accord, is an antimetabolite presented as a sterile injectable solution for intraarterial, intramuscular, and intrathecal use. It is employed in the management of rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, osteosarcoma, and ectopic pregnancy, acting on rapidly dividing cells and immune pathways.

GNH India supplies Methotrexat Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methotrexate is an antimetabolite used in autoimmune, dermatologic and oncologic disease families.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: limits skin cell proliferation and improves plaque lesions.
  • Acute lymphoblastic leukemia: interferes with malignant lymphoblast replication.
  • Osteosarcoma: hampers tumor growth by blocking DNA synthesis.
  • Ectopic pregnancy: terminates trophoblastic tissue when surgery is not feasible.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the availability of reduced folate cofactors required for thymidylate and purine synthesis, thereby impairing DNA replication, repair, and cellular division in rapidly proliferating tissues and immune cells.

Side Effects

Methotrexate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue or malaise.
  • Oral ulcers or mucositis.
  • Elevated liver enzymes.
  • Low blood cell counts (anemia, leukopenia, thrombocytopenia).
  • Skin rash or photosensitivity.

Serious or Rare Side Effects

  • Severe hepatotoxicity or fibrosis.
  • Pulmonary toxicity (interstitial pneumonitis).
  • Renal impairment or failure.
  • Life‑threatening infections due to immunosuppression.
  • Myelosuppression leading to severe pancytopenia.
  • Rare neurotoxicity when administered intrathecally.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated (Category X); avoid use in pregnant or planning patients.
  • Renal function: assess creatinine clearance before initiation and periodically thereafter.
  • Hepatic health: perform baseline liver function tests and monitor during therapy.
  • Hematology: obtain complete blood count prior to treatment and at regular intervals.
  • Concomitant drugs: review for potential interactions that may increase toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several drug classes that can modify its efficacy or toxicity.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate serum levels and risk of toxicity.
  • Proton pump inhibitors (e.g., omeprazole): may reduce renal clearance, enhancing adverse effects.
  • Penicillins (e.g., ampicillin): can impair renal excretion, raising plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Sulfonamides and trimethoprim: additive bone marrow suppression.
  • Azathioprine or other immunosuppressants: heightened risk of infection.
  • Vitamin supplements containing folic acid: may diminish therapeutic effect, requiring dose adjustment.

Frequently Asked Questions

Methotrexat Accord contains methotrexate, which is indicated for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, osteosarcoma, and ectopic pregnancy. It works by targeting rapidly dividing cells and modulating immune responses in these diseases.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing the production of tetrahydrofolate needed for DNA, RNA and protein synthesis. This inhibition limits cell proliferation and suppresses abnormal immune activity, providing therapeutic effects in both cancer and autoimmune conditions.

The specific dose of Methotrexat Accord is determined by the prescribing clinician based on the patient’s condition, weight, renal function and treatment goals. Dosage regimens are individualized and should follow the prescriber’s instructions.

Methotrexat Accord is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal harm. It is also not recommended while breastfeeding because it can be excreted in milk and affect the infant.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Methotrexat Accord, like other methotrexate products, shares the same mechanism of dihydrofolate reductase inhibition. Compared with newer agents such as leflunomide or biologics, methotrexate is less expensive but may require more monitoring for hepatic and hematologic toxicity.

Methotrexat Accord should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the product. If temperature excursions occur, consult the supplier before use.

Methotrexat Accord is supplied as a sterile injectable solution and can be given via intra‑arterial, intramuscular, or intrathecal routes, depending on the indication and prescriber’s plan. Administration should be performed by qualified healthcare professionals using aseptic technique.

Serious risks include severe liver toxicity, pulmonary fibrosis, renal failure, profound bone‑marrow suppression leading to pancytopenia, and life‑threatening infections. Patients should be monitored regularly for signs of these complications.

Methotrexat Accord is contraindicated in pregnant women, patients with known hypersensitivity to methotrexate, those with severe renal or hepatic impairment, and individuals with active infections that could be worsened by immunosuppression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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