Product image of Methotrexate Accord (Methotrexate) supplied by GNH India

Methotrexate Accord

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexate Accord (Methotrexate)

Methotrexate, the active ingredient in Methotrexate Accord, is an Antimetabolite (Folate antagonist) presented as a sterile injectable for intra‑arterial, intramuscular and intrathecal use. It is employed to treat autoimmune disorders and several malignancies in adult and pediatric patients.

GNH India supplies Methotrexate Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Accord Healthcare Limited

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Indications & Clinical Uses

Methotrexate acts on rapidly dividing cells and immune pathways, making it useful across several disease families.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: limits skin cell proliferation and improves plaque lesions.
  • Acute lymphoblastic leukemia: interferes with leukemic cell DNA synthesis, aiding remission.
  • Non‑Hodgkin lymphoma: impedes malignant lymphocyte growth.
  • Gestational trophoblastic disease: promotes resolution of abnormal trophoblastic tissue.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This depletion of tetrahydrofolate reduces the synthesis of purine nucleotides and thymidylate, leading to impaired DNA, RNA and protein production. The resulting cytostatic effect is most pronounced in rapidly dividing cells, including immune cells and malignant clones.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting: gastrointestinal upset that may require anti‑emetic support.
  • Fatigue: persistent tiredness affecting daily activities.
  • Oral mucositis: painful mouth sores and ulceration.
  • Mild liver enzyme elevation: transient increase in transaminases.

Serious or Rare Side Effects

  • Severe bone marrow suppression: pancytopenia requiring close hematologic monitoring.
  • Pulmonary toxicity: interstitial pneumonitis that can be life‑threatening.
  • Hepatotoxicity: significant liver injury or fibrosis with prolonged use.
  • Renal failure: impaired clearance leading to drug accumulation.
  • Opportunistic infections: due to immunosuppression.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated (Category X); avoid use in pregnant patients.
  • Renal function: assess baseline and monitor; dose adjustment may be needed.
  • Liver function: regular liver enzyme testing is recommended.
  • Hematologic monitoring: perform complete blood counts frequently to detect cytopenias.
  • Drug interactions: avoid concurrent NSAIDs and certain antibiotics without supervision.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its safety or efficacy.

Major Interactions (Avoid)

  • NSAIDs: increase risk of renal toxicity and bone marrow suppression.
  • Trimethoprim‑sulfamethoxazole: additive myelosuppression.
  • Live vaccines: heightened infection risk due to immunosuppression.
  • Pemetrexed: overlapping folate antagonism leading to excess toxicity.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may affect gastrointestinal absorption.
  • Phenytoin: can reduce methotrexate plasma levels.
  • Azathioprine: additive immunosuppressive effect requiring blood count monitoring.

Frequently Asked Questions

Methotrexate Accord is indicated for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and gestational trophoblastic disease. In each case the drug works by inhibiting cell proliferation or modulating immune activity to control disease activity.

Methotrexate blocks dihydrofolate reductase, a key enzyme in folate metabolism. This reduces the production of tetrahydrofolate, limiting the synthesis of nucleotides required for DNA and RNA formation. The resulting effect slows the growth of rapidly dividing cells, including immune cells and cancer cells.

The specific dose and schedule of Methotrexate Accord are determined by the prescribing clinician based on the indication, patient weight, renal function and treatment response. Dosing may vary widely, and only a qualified health professional can set the appropriate regimen.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal malformations and miscarriage. It is also not recommended while breastfeeding because it can be excreted in milk and harm the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Methotrexate is a folate antagonist, similar to drugs like pemetrexed and leflunomide. Compared with pemetrexed, methotrexate has a broader range of approved indications, including autoimmune diseases, but may require more intensive monitoring for hepatic and hematologic toxicity.

Methotrexate Accord should be stored at 2‑8 °C, protected from light, and kept in its original packaging to maintain stability. Do not freeze the product, and avoid exposing it to excessive heat or moisture.

The product is supplied as a sterile injectable solution and can be given via intra‑arterial, intramuscular or intrathecal routes, depending on the clinical indication and prescribing physician’s instructions. Administration is performed by qualified healthcare professionals in a controlled setting.

Serious risks include severe bone marrow suppression, hepatotoxicity, pulmonary toxicity, and renal failure. Patients should be monitored regularly for blood counts, liver and kidney function, and any respiratory symptoms to detect complications early.

Methotrexate Accord is contraindicated in pregnant women, patients with severe renal or hepatic impairment, and those with known hypersensitivity to methotrexate or any component of the formulation. Caution is also advised for individuals with active infections or immune deficiencies.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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