Product image of Methotrexate Accord (Methotrexate) supplied by GNH India

Methotrexate Accord

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexate Accord (Methotrexate)

Methotrexate, the active ingredient in Methotrexate Accord, is an antimetabolite presented as a sterile solution for intra‑arterial, intramuscular, and intravenous use. It is employed in the management of rheumatoid arthritis, psoriasis, and selected malignancies such as acute lymphoblastic leukemia and non‑Hodgkin lymphoma.

GNH India supplies Methotrexate Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation to facilitate import and distribution across multiple regions.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methotrexate is an antimetabolite used in diseases where rapid cell proliferation is a key feature.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: limits skin cell overgrowth, improving plaque severity.
  • Acute lymphoblastic leukemia: interferes with malignant cell replication, supporting remission.
  • Non‑Hodgkin lymphoma: impedes tumor growth as part of combination chemotherapy.
  • Gestational trophoblastic disease: induces remission by targeting proliferative trophoblastic tissue.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the synthesis of purine nucleotides and thymidylate, leading to impaired DNA synthesis and cell replication, particularly in rapidly dividing cells such as immune cells and malignant lymphocytes.

Side Effects

Methotrexate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting: gastrointestinal upset occurring shortly after administration.
  • Fatigue: persistent tiredness that may affect daily activities.
  • Oral mucositis: painful sores or ulceration of the mouth lining.
  • Cytopenias: reduced white blood cells, red blood cells, or platelets.
  • Elevated liver enzymes: mild to moderate increases in hepatic transaminases.

Serious or Rare Side Effects

  • Severe hepatotoxicity: potential for liver fibrosis or cirrhosis with prolonged use.
  • Pulmonary fibrosis: interstitial lung disease presenting with cough and dyspnea.
  • Life‑threatening infection: due to profound bone‑marrow suppression.
  • Renal failure: impaired clearance leading to drug accumulation.
  • Anaphylactic reaction: rare hypersensitivity requiring immediate medical attention.

Precautions & Warnings

When using Methotrexate Accord, careful monitoring and patient education are essential.

  • Monitor blood counts: perform regular complete blood count tests to detect cytopenias.
  • Assess liver function: schedule periodic liver enzyme evaluations.
  • Avoid in pregnancy: drug is contraindicated for women who are pregnant or may become pregnant.
  • Use effective contraception: both patients and partners should employ reliable birth control methods.
  • Adjust dose in renal impairment: follow prescriber guidance for patients with reduced kidney function.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Methotrexate can interact with several medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • NSAIDs: concurrent use may increase methotrexate toxicity.
  • Penicillins: can reduce methotrexate clearance, raising plasma levels.
  • Live vaccines: heightened risk of infection when combined with methotrexate.

Moderate Interactions (Monitor Closely)

  • Sulfonamides: additive bone‑marrow suppression potential.
  • Proton pump inhibitors: may affect methotrexate absorption.
  • Azathioprine: combined use can intensify myelosuppression.

Frequently Asked Questions

Methotrexate Accord contains methotrexate, an antimetabolite indicated for rheumatoid arthritis, plaque psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and gestational trophoblastic disease. It works by slowing the growth of rapidly dividing cells involved in these conditions.

Methotrexate blocks the enzyme dihydrofolate reductase, which is needed to produce tetrahydrofolate. Without tetrahydrofolate, cells cannot synthesize purine nucleotides and thymidylate, leading to reduced DNA replication and cell division, especially in immune and cancer cells.

The dose of methotrexate is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and treatment response. Only a qualified health professional should determine the appropriate regimen.

Methotrexate is classified as pregnancy category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as it may be excreted in breast milk and affect the infant.

To request Methotrexate Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Methotrexate is often compared with biologic disease‑modifying agents and other antimetabolites such as azathioprine. Unlike biologics, methotrexate is a small‑molecule drug that can be administered by injection and is generally less expensive, but it may have a broader side‑effect profile requiring regular monitoring.

Methotrexate Accord should be stored at controlled room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability.

The product is supplied as a sterile solution for intra‑arterial, intramuscular, or intravenous injection. Administration is performed by a qualified health professional in a clinical setting, following aseptic technique and the prescriber's instructions.

Serious adverse events include severe liver toxicity, pulmonary fibrosis, life‑threatening infections due to bone‑marrow suppression, and renal failure. Patients should be educated to report symptoms such as persistent jaundice, unexplained cough, fever, or decreased urine output promptly.

Methotrexate is contraindicated in pregnant or breastfeeding individuals, patients with known hypersensitivity to methotrexate, and those with severe renal or hepatic impairment unless dose adjustments are made. Caution is also advised for patients with active infections or pre‑existing lung disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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