Product image of Methotrexate Pfizer (Methotrexate) supplied by GNH India

Methotrexate Pfizer

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexate Pfizer (Methotrexate)

Methotrexate, the active ingredient in Methotrexate Pfizer, is an antimetabolite presented as a oral tablet for oral use. It treats rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, gestational trophoblastic disease and osteosarcoma in appropriate patients.

GNH India supplies Methotrexate Pfizer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pfizer Aps

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Indications & Clinical Uses

Methotrexate is an antimetabolite used in several autoimmune and oncologic disease pathways.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: diminishes skin plaque formation and severity.
  • Acute lymphoblastic leukemia: interferes with malignant cell proliferation.
  • Non‑Hodgkin lymphoma: impedes growth of lymphoma cells.
  • Gestational trophoblastic disease: promotes resolution of trophoblastic tissue.
  • Osteosarcoma: limits tumor cell replication.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the synthesis of purine nucleotides and thymidylate, leading to impaired DNA synthesis and cell replication, particularly affecting rapidly dividing immune and cancer cells.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue or weakness.
  • Oral mucosal ulceration.
  • Mild liver enzyme elevation.
  • Low white blood cell count.
  • Diarrhea.

Serious or Rare Side Effects

  • Severe liver toxicity or fibrosis.
  • Pulmonary fibrosis or interstitial pneumonitis.
  • Life‑threatening infection due to bone‑marrow suppression.
  • Renal failure or nephrotoxicity.
  • Severe cutaneous adverse reactions (e.g., Stevens‑Johnson syndrome).
  • Hematologic malignancies or aplastic anemia.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy contraindication: avoid use in pregnancy (Category X).
  • Liver monitoring: perform regular liver function tests.
  • Hematologic monitoring: check complete blood counts frequently.
  • Renal function: adjust dosing in renal impairment and monitor creatinine.
  • Alcohol avoidance: limit alcohol to reduce hepatic risk.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Methotrexate interacts with several medicines that can alter its safety or efficacy.

Major Interactions (Avoid)

  • NSAIDs: increase methotrexate toxicity.
  • Penicillins and sulfonamides: enhance myelosuppression.
  • Live vaccines: risk of severe infection.
  • Alcohol: potentiates hepatic injury.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase anticoagulant effect.
  • Proton pump inhibitors: can affect absorption.
  • Azathioprine or other immunosuppressants: additive immunosuppression.
  • Allopurinol: may raise methotrexate levels.

Frequently Asked Questions

Methotrexate Pfizer is prescribed for rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, gestational trophoblastic disease and osteosarcoma, where it helps control disease activity or tumor growth.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing the production of tetrahydrofolate needed for DNA synthesis. This limits the replication of rapidly dividing cells, such as immune cells in autoimmune disease and cancer cells in malignancies.

The dose of Methotrexate Pfizer is individualized by the prescribing clinician based on the specific indication, patient characteristics and response. Dosage regimens vary widely and should follow the prescriber’s instructions.

Methotrexate is classified as pregnancy Category X and is contraindicated in pregnancy due to high risk of fetal toxicity. It is also not recommended while breastfeeding because it can be excreted in milk and harm the infant.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Methotrexate is an antimetabolite that directly inhibits DNA synthesis, whereas many other immunosuppressants (e.g., biologic agents) target specific cytokines or cell surface receptors. Methotrexate is often used as a first‑line oral therapy because of its broad efficacy and lower cost, but it may require more laboratory monitoring.

Methotrexate Pfizer should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining a stable room‑temperature environment helps preserve tablet potency.

Methotrexate Pfizer is supplied as an oral tablet and is taken by mouth with or without food, as directed by the prescriber. The exact timing and frequency depend on the therapeutic indication and individual dosing plan.

The most serious risks include severe liver toxicity, pulmonary fibrosis, bone‑marrow suppression leading to life‑threatening infections, and renal failure. Patients should be monitored regularly for signs of organ dysfunction and blood‑cell abnormalities.

Methotrexate Pfizer should not be used by pregnant individuals, those with severe liver disease, uncontrolled renal impairment, active infections, or known hypersensitivity to methotrexate or its excipients. It is also contraindicated in patients receiving live vaccines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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