Product image of Methotrexate Pfizer Healthcare Ireland (Methotrexate) supplied by GNH India

Methotrexate Pfizer Healthcare Ireland

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexate Pfizer Healthcare Ireland (Methotrexate)

Methotrexate, the active ingredient in Methotrexate Pfizer Healthcare Ireland, is an antimetabolite (folate antagonist) presented as a sterile injectable for intra‑arterial, intramuscular and intravenous use. It is employed to treat autoimmune disorders and several types of cancer in adult and pediatric patients.
GNH India supplies Methotrexate Pfizer Healthcare Ireland as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Pfizer Healthcare Ireland Unlimited Company

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Indications & Clinical Uses

Methotrexate is used across a range of autoimmune and oncologic disease pathways.

  • Rheumatoid arthritis: reduces disease activity and joint inflammation.
  • Psoriasis: decreases skin plaque formation and severity.
  • Acute lymphoblastic leukemia: interferes with malignant cell proliferation.
  • Non‑Hodgkin lymphoma: induces tumor cell death.
  • Breast cancer: inhibits tumor growth as part of combination regimens.
  • Osteosarcoma: limits bone tumor progression.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the cellular pool of tetrahydrofolate needed for synthesis of purine nucleotides and thymidylate, thereby impairing DNA, RNA and protein synthesis in rapidly dividing cells and modulating immune cell activity.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Fatigue or malaise
  • Oral mucosal ulceration
  • Mild elevation of liver enzymes
  • Transient low white blood cell counts
  • Mild alopecia

Serious or Rare Side Effects

  • Severe hepatic toxicity or fibrosis
  • Pulmonary fibrosis or interstitial pneumonitis
  • Life‑threatening bone marrow suppression
  • Acute renal failure
  • Severe infection due to immunosuppression
  • Anaphylactic or severe hypersensitivity reactions

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy: contraindicated (Category X); avoid use in women of childbearing potential unless effective contraception is used.
  • Renal function: assess baseline and monitor renal parameters; dose adjustment may be needed.
  • Hepatic function: perform liver function tests regularly; discontinue if significant toxicity occurs.
  • Hematologic monitoring: conduct complete blood counts before each dose to detect marrow suppression.
  • Concomitant NSAIDs or nephrotoxic drugs: avoid or use with caution due to increased renal risk.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Methotrexate interacts with several drug classes that may alter its safety or efficacy.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase methotrexate toxicity.
  • Sulfonamide antibiotics (e.g., trimethoprim‑sulfamethoxazole): potentiate bone marrow suppression.
  • Live vaccines: risk of severe infection due to immunosuppression.
  • Other folate antagonists (e.g., pemetrexed): additive toxicity.
  • High‑dose aspirin: may impair renal clearance.

Moderate Interactions (Monitor Closely)

  • Azathioprine or cyclosporine: enhanced immunosuppressive effect.
  • Carbamazepine or phenytoin: may reduce methotrexate plasma levels.
  • Oral contraceptives: possible reduced efficacy; advise alternative contraception.

Frequently Asked Questions

Methotrexate Pfizer Healthcare Ireland is indicated for several autoimmune and oncologic conditions, including rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma, breast cancer, and osteosarcoma. It works by interfering with cell proliferation and immune activity, helping to control disease progression and symptoms.

Methotrexate blocks the enzyme dihydrofolate reductase, which is essential for producing tetrahydrofolate. This reduction limits the synthesis of nucleotides required for DNA, RNA and protein production, thereby inhibiting the growth of rapidly dividing cells and modulating immune responses.

The specific dose of methotrexate is determined by the prescribing healthcare professional based on the patient’s condition, weight, renal and hepatic function, and treatment goals. Dosage regimens can vary widely between autoimmune disorders and cancer protocols.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to a high risk of fetal malformations and miscarriage. It is also excreted in breast milk, so breastfeeding is not recommended while receiving this medication.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Methotrexate is a folate antagonist, whereas other antimetabolites such as pemetrexed or 5‑fluorouracil target different enzymes in nucleotide synthesis. Methotrexate has a broad therapeutic range covering both autoimmune diseases and various cancers, but its safety profile requires careful monitoring of liver, kidney and blood parameters.

Methotrexate Pfizer Healthcare Ireland should be stored at ambient temperature, below 25 °C. Keep the vials in their original packaging, protect them from moisture and direct sunlight, and avoid freezing.

The product is supplied as a sterile injectable solution and can be given via intra‑arterial, intramuscular or intravenous routes, depending on the clinical indication and prescribing physician’s instructions. Administration is performed by qualified healthcare professionals in a controlled setting.

Serious risks include severe liver toxicity, pulmonary fibrosis, life‑threatening bone marrow suppression, acute renal failure, and severe infections. Patients should be monitored regularly for signs of organ dysfunction and blood count abnormalities, and any concerning symptoms should prompt immediate medical evaluation.

Methotrexate is contraindicated in pregnant women, individuals with severe renal or hepatic impairment, patients with known hypersensitivity to methotrexate or its excipients, and those receiving live vaccines. It should also be used with caution in patients with pre‑existing blood disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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