Product image of Methotrexate Teva (Methotrexate) supplied by GNH India

Methotrexate Teva

Active Ingredient:
Methotrexate
Origin:
EU

Methotrexate Teva (Methotrexate)

Methotrexate, the active ingredient in Methotrexate Teva, is a folate antagonist presented as a parenteral preparation for epidural, intrabursal, and intracoronary administration. It is employed in the management of rheumatoid arthritis, psoriasis, certain leukemias, osteosarcoma, and ectopic pregnancy in adult patients.

GNH India supplies Methotrexate Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Methotrexate Teva acts as a folate pathway inhibitor used across several disease families.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: diminishes skin plaque formation and severity.
  • Acute lymphoblastic leukemia: interferes with malignant cell proliferation.
  • Osteosarcoma: limits tumor growth in bone.
  • Ectopic pregnancy: halts trophoblastic tissue development.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, decreasing tetrahydrofolate production. This blocks the synthesis of purine and pyrimidine nucleotides, leading to reduced DNA, RNA, and protein synthesis in rapidly dividing cells, thereby exerting immunosuppressive and cytotoxic effects.

Side Effects

Methotrexate may cause a range of adverse reactions.

Common Side Effects

  • Nausea and vomiting.
  • Fatigue or malaise.
  • Oral mucosal ulceration.
  • Mild liver enzyme elevation.
  • Transient low white blood cell count.
  • Mild skin rash.

Serious or Rare Side Effects

  • Severe hepatotoxicity or fibrosis.
  • Pulmonary fibrosis or interstitial pneumonitis.
  • Life‑threatening bone marrow suppression.
  • Acute renal failure.
  • Severe cutaneous adverse reactions (e.g., Stevens‑Johnson syndrome).
  • Opportunistic infections due to immunosuppression.

Precautions & Warnings

Before initiating therapy, several safety considerations are required.

  • Pregnancy: contraindicated (Category X) – avoid use in pregnant women.
  • Renal function: assess baseline creatinine and adjust if impaired.
  • Liver function: monitor transaminases regularly.
  • Hematologic status: perform complete blood counts before and during treatment.
  • Drug interactions: review concomitant medications for potential additive toxicity.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Methotrexate interacts with several medicines that may alter its safety or efficacy.

Major Interactions (Avoid)

  • NSAIDs: increase risk of renal toxicity and gastrointestinal ulceration.
  • Trimethoprim‑sulfamethoxazole: potentiate bone‑marrow suppression.
  • Live vaccines: heightened risk of infection.
  • Radiation therapy: may exacerbate tissue damage.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may affect methotrexate absorption.
  • Leucovorin rescue: dosing adjustments may be needed.
  • Azathioprine: additive immunosuppressive effect requiring close monitoring.

Frequently Asked Questions

Methotrexate Teva is a folate antagonist employed as a disease‑modifying antirheumatic drug for rheumatoid arthritis and psoriasis, and as an antineoplastic agent for acute lymphoblastic leukemia, osteosarcoma, and ectopic pregnancy. It works by inhibiting cell proliferation in both inflammatory and malignant conditions.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing tetrahydrofolate levels. This limits the synthesis of nucleotides required for DNA, RNA, and protein production, thereby suppressing rapidly dividing immune cells and cancer cells.

The specific dose and dosing schedule of Methotrexate Teva are determined by the prescribing clinician based on the indication, patient weight, renal and hepatic function, and treatment response. No universal dosing regimen is provided here.

Methotrexate is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy due to a high risk of fetal malformations and miscarriage. It is also not recommended while breastfeeding because it can be excreted in breast milk.

To order Methotrexate Teva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with biologic DMARDs, methotrexate is an oral or parenteral small‑molecule agent that is less expensive but may require more laboratory monitoring. In oncology, it offers a distinct mechanism from alkylating agents and taxanes, providing an alternative for patients with specific hematologic or solid‑tumor indications.

Methotrexate Teva should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and handle with gloves if the formulation is a parenteral solution.

Methotrexate Teva is supplied for parenteral use and may be given via epidural, intrabursal, or intracoronary injection, depending on the clinical indication. Administration is performed by qualified healthcare professionals following aseptic technique.

Serious risks include severe liver toxicity, pulmonary fibrosis, life‑threatening bone‑marrow suppression, acute renal failure, and severe cutaneous reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for signs of organ dysfunction and infection.

Methotrexate Teva should not be used by pregnant women, individuals with severe renal or hepatic impairment, patients with uncontrolled infections, or those who have had hypersensitivity reactions to methotrexate or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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