Methoxsalen Macopharma (Methoxsalen)

Methoxsalen intercalates into DNA and, when activated by UVA light, creates covalent cross‑links that block DNA synthesis. This inhibition curtails abnormal skin cell proliferation and modulates immune activity, providing therapeutic benefit in targeted skin disorders.

The specific dose of methoxsalen is determined by the prescribing clinician based on the patient’s condition, skin type, and UVA treatment protocol. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for methoxsalen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Methoxsalen is a classic psoralen used with UVA (PUVA) therapy. Compared with newer biologics, it offers a non‑systemic option that directly targets skin cells but requires careful UVA dosing and monitoring for phototoxicity, whereas biologics act systemically and have different safety profiles.

Store Methoxsalen Macopharma at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and avoid exposure to extreme temperatures.

Methoxsalen is administered extracorporeally, typically as an oral preparation taken before a scheduled UVA exposure session. The exact administration schedule is set by the treating physician and coordinated with phototherapy timing.

Serious risks include severe phototoxic burns, hemolysis in patients with G6PD deficiency, liver enzyme elevation, myelosuppression, and rare hypersensitivity reactions such as anaphylaxis. Patients should be monitored closely for these events.

Methoxsalen should be avoided in individuals with known hypersensitivity to psoralens, active skin infections, uncontrolled liver disease, G6PD deficiency, or those who cannot safely undergo UVA exposure. Contraindications must be evaluated by a healthcare professional.