Methoxsalen Macopharma (Methoxsalen)

Methoxsalen intercalates into DNA and, when activated by UVA light, creates cross‑links that inhibit DNA synthesis. This suppresses abnormal skin cell growth and stimulates melanocyte activity, addressing the underlying pathology of psoriasis and vitiligo.

The specific dose of methoxsalen is determined by the prescribing clinician based on the patient’s condition, weight, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for methoxsalen in pregnancy and lactation are limited. It should only be used if the potential benefits justify the potential risks to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Methoxsalen is the primary psoralen used in PUVA therapy and shares a similar efficacy profile with other psoralens. Differences may lie in formulation, stability, and regulatory status, but clinical outcomes are generally comparable when used under the same phototherapy protocol.

Methoxsalen Macopharma should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light to maintain its stability.

Methoxsalen is administered extracorporeally, typically as an oral preparation taken prior to controlled exposure to UVA light during PUVA sessions. The exact administration schedule is defined by the treating physician.

Serious risks include severe phototoxic skin reactions, increased long‑term risk of skin cancer, hepatic toxicity, and cataract formation with prolonged use. Patients should be monitored regularly for these adverse events.

Methoxsalen is contraindicated in individuals with known hypersensitivity to psoralens, active skin infections, uncontrolled liver disease, or those who are unable to avoid excessive UVA exposure. It should also be used with caution in patients with a history of skin cancer.