Product image of Methoxsalene Macopharma (Methoxsalen) supplied by GNH India

Methoxsalene Macopharma

Active Ingredient:
Methoxsalen
Origin:
EU

Methoxsalene Macopharma (Methoxsalen)

Methoxsalen, the active ingredient in Methoxsalene Macopharma, is a psoralen presented as a pharmaceutical preparation for extracorporeal use. It is employed in PUVA therapy to treat chronic skin conditions such as psoriasis and vitiligo in adult patients.

GNH India supplies Methoxsalene Macopharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Maco Pharma

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Methoxsalen is used as a photosensitizing agent in PUVA therapy for several dermatologic conditions.
  • Psoriasis: improves plaque clearance and reduces scaling when combined with UVA exposure.
  • Vitiligo: promotes repigmentation of depigmented patches during PUVA treatment.
  • Cutaneous T‑cell lymphoma: used as part of PUVA regimens to control skin lesions.

How It Works

  • Methoxsalen intercalates into DNA strands and, upon activation by UVA light, forms covalent cross‑links that inhibit DNA synthesis and cell proliferation. This photochemical reaction reduces hyperproliferative keratinocyte activity and modulates immune responses in the skin, facilitating therapeutic effects in PUVA protocols.

Side Effects

Methoxsalen may cause a range of adverse reactions, most of which are related to its photosensitizing properties.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Erythema: mild skin redness after UVA exposure.
  • Hyperpigmentation: localized darkening of treated skin.
  • Pruritus: itching in exposed areas.
  • Photosensitivity: heightened skin reaction to light.

Serious or Rare Side Effects

  • Severe phototoxic burns: extensive skin damage after UVA.
  • Blistering: formation of vesicles on irradiated skin.
  • Erythema multiforme: target‑like skin lesions.
  • Stevens‑Johnson syndrome: severe mucocutaneous reaction.
  • Bone marrow suppression: decreased blood cell counts.
  • Hepatic toxicity: abnormal liver function tests.

Precautions & Warnings

  • Methoxsalen requires careful patient assessment and monitoring to minimize risks.
  • Assess skin type: evaluate susceptibility to phototoxic reactions.
  • Avoid sun exposure: limit UVA exposure for 24 hours post‑administration.
  • Monitor blood counts: perform periodic hematologic testing.
  • Check liver function: obtain baseline and follow‑up liver enzymes.
  • Pregnancy: contraindicated unless benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Methoxsalen can interact with other medications, altering its safety profile.

Major Interactions (Avoid)

  • Other photosensitizing drugs: increase risk of severe skin reactions.
  • Systemic retinoids: amplify phototoxicity.
  • Azathioprine: may enhance bone marrow suppression.
  • Thiazide diuretics: potentiate photosensitivity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduced efficacy.
  • Antifungal azoles: may affect metabolism.
  • SSRIs: monitor for additive side effects.

Frequently Asked Questions

Methoxsalene Macopharma contains methoxsalen, a psoralen used in PUVA (psoralen + UVA) therapy to treat chronic skin disorders such as psoriasis and vitiligo by enhancing the skin’s response to controlled UVA exposure.

Methoxsalen intercalates into DNA and, when activated by UVA light, creates covalent cross‑links that block DNA synthesis and cell proliferation. This reduces abnormal skin cell growth and modulates immune activity, leading to clinical improvement in PUVA‑treated conditions.

The dosage of methoxsalen is individualized by the prescribing clinician based on the specific indication, patient characteristics, and the planned UVA exposure schedule. Only a qualified healthcare professional should determine the appropriate regimen.

Methoxsalen is classified as contraindicated in pregnancy unless the potential benefit justifies the risk, because it can cross the placenta and cause fetal harm. Limited data exist for breastfeeding; caution is advised and a risk‑benefit assessment should be performed by the prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Methoxsalen is the most widely used psoralen for PUVA therapy due to its well‑characterized pharmacokinetics and efficacy. Alternative agents, such as 8‑methoxypsoralen, have similar mechanisms but may differ in dosing convenience or side‑effect profiles. Choice depends on clinical judgment and patient tolerance.

Store the product at ambient temperature, below 25 °C, in its original packaging. Protect it from moisture and direct light to maintain stability. No refrigeration is required for this extracorporeal preparation.

Methoxsalene Macopharma is supplied for extracorporeal use. The prescribed dose is taken orally (or as directed) prior to a scheduled UVA exposure session, typically 2 hours before irradiation, under medical supervision.

Serious risks include severe phototoxic burns, blistering, erythema multiforme, Stevens‑Johnson syndrome, bone marrow suppression, and hepatic toxicity. Patients should be monitored closely for these reactions, especially after UVA exposure.

Methoxsalen is contraindicated in patients with a history of severe photosensitivity, active skin infections, uncontrolled liver disease, significant hematologic disorders, or those who are pregnant without a clear therapeutic justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Methoxsalen

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT