Product image of Methergín (Methylergometrine) supplied by GNH India

Methergín

Active Ingredient:
Methylergometrine
Origin:
EU

Methergín (Methylergometrine)

Methylergometrine, the active ingredient in Methergín, is an ergot alkaloid presented as a sterile injectable solution for intramuscular, intravenous, or subcutaneous use. It is employed to prevent and treat postpartum hemorrhage and to manage uterine atony in obstetric patients.

GNH India supplies Methergín as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Essential Pharma Limited

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Indications & Clinical Uses

Methergín is used in obstetrics to address conditions that involve uterine muscle tone and bleeding.

  • Postpartum hemorrhage: helps control excessive bleeding after delivery.
  • Uterine atony: stimulates uterine contraction when the uterus fails to contract spontaneously.
  • Induction of labor (in some protocols): promotes cervical ripening and uterine activity to initiate labor.

How It Works

  • Methylergometrine acts as a partial agonist at 5‑HT2 serotonin receptors and alpha‑adrenergic receptors on uterine smooth muscle, causing sustained contraction of the uterus and vasoconstriction of uterine vessels, which reduces bleeding and facilitates labor progression.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Hypertension: transient increase in blood pressure.
  • Headache: pressure or throbbing sensation.
  • Flushing: redness of the skin, especially face.

Serious or Rare Side Effects

  • Severe hypertension: marked elevation of blood pressure requiring medical attention.
  • Coronary spasm: chest pain due to reduced coronary blood flow.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

Careful assessment and monitoring are required when using Methergín.

  • Cardiovascular assessment: evaluate blood pressure and heart status before administration.
  • Monitor blood pressure: observe for hypertension during and after dosing.
  • Caution in hypertension: avoid or use reduced dose in patients with pre‑existing high blood pressure.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Obstetric supervision: administer only under qualified obstetric care.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Methylergometrine may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertension.
  • Other ergot derivatives: additive vasoconstrictive effects.
  • Strong CYP3A4 inhibitors: increased plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible reduction in efficacy.
  • Calcium channel blockers: may enhance vasoconstriction.

Frequently Asked Questions

Methergín contains methylergometrine and is used in obstetric care to prevent and treat postpartum hemorrhage, manage uterine atony, and in some protocols to help induce labor by promoting uterine contraction.

Methylergometrine stimulates uterine smooth‑muscle contraction by partially activating 5‑HT2 serotonin receptors and alpha‑adrenergic receptors, while also causing vasoconstriction of uterine vessels, which together reduce bleeding and support labor.

The specific dose of Methergín is determined by the prescribing obstetrician or qualified healthcare professional based on the clinical situation, patient characteristics, and local guidelines.

Methylergometrine is intended for use in the peripartum period under medical supervision. Its safety profile in ongoing pregnancy or breastfeeding has not been fully established, so it should be used only when clearly indicated by a healthcare provider.

To place an order, submit an enquiry on the Methergín product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Methergín (methylergometrine) is an ergot alkaloid uterotonic, offering a longer duration of uterine contraction compared with oxytocin but with a higher risk of vasoconstrictive side effects. Choice of agent depends on clinical context, patient tolerance, and provider preference.

Methergín should be stored at ambient temperature, below 25 °C, in its original packaging, protected from moisture, light, and extreme temperature fluctuations to maintain stability.

Methergín is supplied as a sterile injectable solution and can be given intramuscularly, intravenously, or subcutaneously by a qualified healthcare professional according to the prescribed dose and route.

Serious risks include severe hypertension, coronary artery spasm, pulmonary edema, thromboembolic events, and rare cases of ergotism. Prompt recognition and medical intervention are essential if these events occur.

Methergín is contraindicated in patients with known hypersensitivity to ergot alkaloids, uncontrolled hypertension, active coronary artery disease, or those taking monoamine oxidase inhibitors. It should also be avoided in individuals where uterine contraction is not desired.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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