Product image of Methylergometrinmaleat Zur Anwendung Bei Erwachsenen Frauen Panpharma (Methylergometrine Maleate) supplied by GNH India

Methylergometrinmaleat Zur Anwendung Bei Erwachsenen Frauen Panpharma

Active Ingredient:
Methylergometrine Maleate
Origin:
EU

Methylergometrinmaleat Zur Anwendung Bei Erwachsenen Frauen Panpharma (Methylergometrine Maleate)

Methylergometrine maleate, the active ingredient in Methylergometrinmaleat Zur Anwendung Bei Erwachsenen Frauen Panpharma, is an ergot alkaloid presented as an injectable for intramuscular or intravenous use. It is employed to prevent and treat postpartum hemorrhage and uterine atony in adult women.

GNH India supplies Methylergometrinmaleat Zur Anwendung Bei Erwachsenen Frauen Panpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Panpharma Gmbh

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Indications & Clinical Uses

Methylergometrine maleate is a uterotonic agent used in obstetric care to manage bleeding and uterine tone.

  • Postpartum hemorrhage: promotes rapid uterine contraction to reduce blood loss.
  • Uterine atony: restores muscle tone when the uterus fails to contract after delivery.
  • Prevention of excessive bleeding: administered prophylactically during the third stage of labor to minimize hemorrhage risk.

How It Works

  • Methylergometrine maleate acts as an agonist at serotonin (5‑HT2), dopamine and alpha‑adrenergic receptors on uterine smooth muscle. Stimulation of these receptors increases intracellular calcium, leading to sustained uterine contraction and reduced uterine blood flow, thereby helping control postpartum bleeding.

Side Effects

Methylergometrine maleate may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Hypertension: temporary rise in blood pressure.
  • Flushing: reddening of the skin.

Serious or Rare Side Effects

  • Coronary artery spasm: severe chest pain requiring immediate care.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Uterine rupture: rare but life‑threatening tearing of the uterus.
  • Severe allergic reaction: anaphylaxis with rash, swelling, or breathing difficulty.

Precautions & Warnings

Use methylergometrine maleate with caution and under obstetric supervision.

  • Blood pressure monitoring: check for hypertension before and after administration.
  • Cardiovascular disease: avoid in patients with known coronary artery disease.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Concomitant vasoconstrictors: avoid combining with other ergot derivatives.
  • Storage: Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Methylergometrine maleate can interact with several drug classes.

Major Interactions (Avoid)

  • Ergotamine or other ergot derivatives: additive vasoconstriction.
  • Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increased plasma levels.

Moderate Interactions (Monitor Closely):\n- Alpha‑adrenergic blockers: may blunt uterine contraction.

  • Calcium channel blockers: possible additive cardiovascular effects.
  • SSRIs: monitor for serotonergic excess.

Frequently Asked Questions

Methylergometrinmaleat contains methylergometrine maleate, a uterotonic drug used to prevent and treat postpartum hemorrhage and to manage uterine atony in adult women after delivery.

The compound activates serotonin (5‑HT2), dopamine and alpha‑adrenergic receptors on uterine smooth muscle, increasing calcium influx and causing strong, sustained uterine contractions that help stop bleeding.

The specific dose and route are determined by the prescribing obstetrician or surgeon based on the clinical situation and patient characteristics.

Methylergometrine is intended for use after delivery; its safety in pregnancy is not established, and it is generally not recommended for breastfeeding mothers without medical guidance.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with oxytocin, methylergometrine provides a longer‑lasting uterine contraction and is particularly useful when oxytocin alone is insufficient, though it carries a higher risk of hypertension and vasospasm.

Store the injectable at ambient temperature, preferably below 25 °C, in the original packaging and protect it from moisture and direct light.

It is given by a healthcare professional as an intramuscular or intravenous injection, usually in a controlled clinical setting such as an operating theatre or delivery suite.

Serious risks include severe hypertension, coronary artery spasm, pulmonary edema, uterine rupture and rare anaphylactic reactions; patients should be monitored closely for these events.

Patients with uncontrolled hypertension, known coronary artery disease, hypersensitivity to ergot alkaloids, or those taking interacting vasoconstrictive agents should avoid methylergometrine unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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