Product image of Metoclopramid Polpharma (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramid Polpharma

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramid Polpharma (Metoclopramide Hydrochloride)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramid Polpharma, is a dopamine antagonist presented as an unknown/unknown for intramuscular, intravenous use. It is employed to control nausea, vomiting and to improve gastric emptying in several clinical settings.

GNH India supplies Metoclopramid Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Metoclopramid Polpharma acts on the dopaminergic pathways that trigger nausea and on gastrointestinal motility. It is indicated for:

  • Nausea and vomiting: reduces episodes caused by chemotherapy, surgery or other triggers.
  • Gastroparesis: enhances gastric emptying and alleviates related symptoms.
  • Migraine‑associated nausea: helps control nausea accompanying migraine attacks.

How It Works

  • Metoclopramide Hydrochloride blocks dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the vomiting reflex. Simultaneously it increases acetylcholine release in the gastrointestinal tract, promoting coordinated smooth‑muscle contractions that accelerate gastric emptying and improve intestinal transit.

Side Effects

Metoclopramid Polpharma may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inner sense of agitation or inability to stay still.
  • Diarrhea: loose or watery stools.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or tremors.
  • Tardive dyskinesia: persistent, potentially irreversible facial or limb movements.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and muscle rigidity.

Precautions & Warnings

Before using Metoclopramid Polpharma, consider the following safety measures.

  • Renal function assessment: adjust use in patients with impaired kidney function.
  • Extrapyramidal monitoring: watch for signs of involuntary movements.
  • Depression caution: use carefully in patients with a history of depression.
  • Hypersensitivity check: avoid if known allergy to metoclopramide or excipients.
  • Elderly use: start at lower doses and monitor closely.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metoclopramid Polpharma can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): may increase risk of extrapyramidal effects.
  • Monoamine oxidase inhibitors (MAOIs): can potentiate central nervous system depression.
  • Opioid analgesics: may enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Antihistamines: may increase drowsiness.
  • Alcohol: can amplify central nervous system depressive effects.

Frequently Asked Questions

Metoclopramid Polpharma is prescribed to treat nausea and vomiting from various causes, to improve gastric emptying in gastroparesis, and to manage nausea that accompanies migraine attacks. It works by influencing dopamine pathways and enhancing gastrointestinal motility.

The drug blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the stimulus to vomit. At the same time it increases acetylcholine release in the gut, stimulating coordinated muscle contractions that speed up gastric emptying and intestinal transit.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, age, weight, renal function and response to therapy. Dosage regimens can vary widely, so the prescriber sets the exact amount and schedule.

Safety data for use in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Metoclopramide is a dopamine antagonist, whereas many other anti‑emetics such as ondansetron are serotonin 5‑HT3 antagonists. Metoclopramide also has pro‑kinetic activity, helping gastric motility, a property not shared by most pure anti‑emetics.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight and sources of heat to maintain stability and potency.

The medication is supplied for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional using aseptic technique, following the dosage and infusion rate prescribed for the individual patient.

Serious adverse effects include extrapyramidal symptoms such as acute dystonia, tardive dyskinesia, and the rare neuroleptic malignant syndrome. Prompt recognition and medical attention are essential if these reactions occur.

Patients with known hypersensitivity to metoclopramide or any excipients, those with pheochromocytoma, uncontrolled epilepsy, or severe depression should avoid the drug. It is also contraindicated in individuals taking MAO inhibitors within the past 14 days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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