Product image of Metoclopramid Terapia (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramid Terapia

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramid Terapia (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide, the active ingredient in Metoclopramid Terapia, is a dopamine D2 receptor antagonist presented as an injectable solution for intramuscular and intravenous use. It is employed to treat nausea, vomiting and gastroparesis in adult patients.
GNH India supplies Metoclopramid Terapia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

Metoclopramide is used to manage conditions related to nausea, vomiting and delayed gastric emptying.

  • Nausea and vomiting: reduces the frequency and severity of episodes.
  • Post‑operative nausea and vomiting: prevents symptoms after surgical procedures.
  • Gastroparesis: enhances gastric motility and improves stomach emptying.

How It Works

  • Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the vomiting reflex, while simultaneously stimulating acetylcholine release in the gastrointestinal wall, which increases smooth‑muscle contractility and promotes gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy.
  • Fatigue: reduced energy levels.
  • Restlessness: inability to stay still.
  • Diarrhea: loose, frequent stools.
  • Headache: mild to moderate pain.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Extrapyramidal reactions: involuntary muscle movements.
  • Tardive dyskinesia: persistent involuntary facial movements.
  • Neuroleptic malignant syndrome: life‑threatening hyperthermia.
  • Depression: worsening mood or suicidal thoughts.
  • Seizures: convulsive episodes.
  • Anaphylaxis: severe allergic reaction.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal and hepatic assessment: evaluate function to adjust dosing if needed.
  • Extrapyramidal monitoring: watch for involuntary movements, especially in high‑risk patients.
  • Depression screening: be cautious in individuals with a history of mood disorders.
  • Hypersensitivity check: avoid use in patients with known allergy to metoclopramide.
  • Elderly caution: start with the lowest effective dose and monitor closely.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Antipsychotics: increased risk of extrapyramidal symptoms.
  • MAO inhibitors: potential for hypertensive crisis.
  • CNS depressants: enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors: may raise metoclopramide plasma levels.
  • Anticholinergics: could reduce gastrointestinal pro‑kinetic effect.
  • Opioids: additive effects on gastrointestinal motility and sedation.

Frequently Asked Questions

Metoclopramid Terapia is indicated for the treatment of nausea and vomiting, prevention of postoperative nausea and vomiting, and management of gastroparesis, where it helps improve gastric emptying and reduce symptoms.

Metoclopramide works by blocking dopamine D2 receptors in the chemoreceptor trigger zone, which suppresses the vomiting reflex, and by increasing acetylcholine release in the gastrointestinal tract, which enhances motility and promotes faster gastric emptying.

The appropriate dose of Metoclopramid Terapia is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal or hepatic function. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Metoclopramid Terapia in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramid Terapia differs from many antiemetics by combining dopamine antagonism with pro‑kinetic activity, making it effective for both nausea control and gastric motility. Alternatives such as ondansetron act primarily on serotonin receptors and lack the pro‑kinetic effect.

Metoclopramid Terapia should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain stability.

The medication is supplied for parenteral use and can be given by intramuscular or intravenous injection. Administration technique and rate should follow the prescribing clinician’s guidance and institutional protocols.

Serious risks include extrapyramidal reactions such as tardive dyskinesia, neuroleptic malignant syndrome, severe depression or suicidal thoughts, and rare allergic reactions like anaphylaxis. Patients should be monitored closely for these events.

Metoclopramid Terapia is contraindicated in individuals with known hypersensitivity to metoclopramide or any component of the formulation, and it should be used with caution in patients with a history of seizure disorders, severe depression, or Parkinson’s disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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