Product image of Metoclopramid Terapia (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramid Terapia

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramid Terapia (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride Monohydrate, the active ingredient in Metoclopramid Terapia, is a dopamine antagonist (antiemetic) presented as an oral tablet for oral use. It is used to treat nausea, vomiting, gastroparesis, and related gastrointestinal disorders in adult patients.
GNH India supplies Metoclopramid Terapia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

Metoclopramide acts on the gastrointestinal and central nervous systems to relieve symptoms associated with several disorders.

  • Nausea and vomiting: reduces acute and delayed episodes caused by surgery, medication, or other triggers.
  • Gastroparesis: improves gastric emptying and alleviates related discomfort.
  • Gastro‑oesophageal reflux disease (GERD): decreases reflux episodes by enhancing motility.
  • Chemotherapy‑induced nausea: prevents or lessens nausea associated with cytotoxic agents.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, blocks 5‑HT3 receptors, and increases acetylcholine release. These actions together enhance gastric emptying, increase lower‑esophageal sphincter tone, and suppress the central vomiting reflex, thereby reducing nausea and facilitating gastrointestinal motility.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Fatigue: general lack of energy.
  • Diarrhea: loose or watery stools.
  • Restlessness: feeling uneasy or unable to stay still.
  • Headache: mild to moderate head pain.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or involuntary movements.
  • Tardive dyskinesia: persistent involuntary facial movements with long‑term use.
  • Neuroleptic malignant syndrome: rare, life‑threatening reaction with fever and muscle rigidity.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Cardiac arrhythmias: irregular heartbeats in susceptible individuals.

Precautions & Warnings

Metoclopramide should be used with caution in specific clinical situations.

  • Pregnancy: avoid unless clearly needed; limited safety data are available.
  • Breastfeeding: consider potential drug exposure to the infant.
  • Elderly patients: monitor for increased risk of extrapyramidal effects.
  • Renal impairment: dose adjustment may be required.
  • History of movement disorders: assess risk of worsening symptoms.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metoclopramide can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive risk of extrapyramidal symptoms.
  • MAO inhibitors: increased risk of hypertensive crisis.
  • CNS depressants (e.g., opioids, benzodiazepines): enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): possible altered plasma levels.
  • Anticholinergic agents: may reduce pro‑kinetic effect.
  • Antihistamines: potential increase in drowsiness.
  • Digoxin: monitor for altered cardiac effects.

Frequently Asked Questions

Metoclopramid Terapia contains metoclopramide, an antiemetic and gastro‑prokinetic agent. It is prescribed to relieve nausea and vomiting, treat gastroparesis, manage gastro‑oesophageal reflux disease, and prevent chemotherapy‑induced nausea in adult patients.

Metoclopramide works by blocking dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract, inhibiting 5‑HT3 receptors, and enhancing acetylcholine release. These actions promote gastric emptying, increase lower‑esophageal sphincter tone, and suppress the central vomiting reflex.

The dosage of Metoclopramid Terapia is determined by the prescribing clinician based on the patient’s condition, severity, and response. The prescriber will set the appropriate dose and treatment duration according to clinical guidelines.

Safety data for metoclopramide in pregnancy are limited, and it should only be used when clearly needed. Breastfeeding mothers should consider potential drug exposure to the infant and discuss risks with their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Metoclopramide differs from many antiemetics by also having pro‑kinetic activity, enhancing gastric motility. Compared with agents such as ondansetron, which primarily block serotonin receptors, metoclopramide adds dopamine antagonism and can be useful when delayed gastric emptying contributes to symptoms.

Metoclopramid Terapia should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency.

The medication is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water and follow the dosing schedule provided by the healthcare professional.

Serious risks include extrapyramidal symptoms such as muscle rigidity or tremor, tardive dyskinesia with long‑term use, neuroleptic malignant syndrome, severe allergic reactions, and cardiac arrhythmias in susceptible patients. Prompt medical attention is required if these occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, and individuals with a history of severe extrapyramidal reactions. Caution is also advised for patients with gastrointestinal obstruction, perforation, or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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