Product image of Metoclopramida Accord (Metoclopramide Hydrochloride Anhydrous) supplied by GNH India

Metoclopramida Accord

Active Ingredient:
Metoclopramide Hydrochloride Anhydrous
Origin:
EU

Metoclopramida Accord (Metoclopramide Hydrochloride Anhydrous)

Metoclopramide, the active ingredient in Metoclopramida Accord, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It treats nausea and vomiting, gastroparesis, and gastro‑oesophageal reflux disease in adult patients.
GNH India supplies Metoclopramida Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Metoclopramida Accord acts on dopamine pathways that influence nausea, gastric motility and reflux.

  • Nausea and vomiting: reduces the frequency and severity of episodes.
  • Gastroparesis: enhances gastric emptying and relieves associated symptoms.
  • Gastro‑oesophageal reflux disease: improves lower oesophageal sphincter tone and decreases reflux episodes.

How It Works

  • Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the vomiting reflex, and stimulates acetylcholine release in the gastrointestinal tract, which increases smooth‑muscle contractility and promotes gastric emptying.

Side Effects

Metoclopramida Accord may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inner sense of agitation or inability to stay still.
  • Diarrhoea: loose, frequent stools.
  • Dry mouth: reduced salivation.
  • Headache: mild to moderate head pain.
  • Fatigue: general lack of energy.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or tremors.
  • Tardive dyskinesia: persistent, potentially irreversible facial or tongue movements.
  • Neuroleptic malignant syndrome: rare, life‑threatening reaction with fever and rigidity.
  • Depression or suicidal thoughts: mood changes requiring immediate attention.
  • Seizures: convulsive episodes.
  • Hyperprolactinemia: elevated prolactin leading to hormonal disturbances.

Precautions & Warnings

Before prescribing Metoclopramida Accord, clinicians should consider several safety measures.

  • Assess renal function: dose adjustment may be needed in impaired kidneys.
  • Monitor for extrapyramidal symptoms: watch for muscle rigidity or tremor.
  • Use the lowest effective dose: limit exposure to reduce risk of tardive dyskinesia.
  • Avoid prolonged therapy: limit use to the shortest duration necessary.
  • Contraindicated in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metoclopramida Accord can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Antipsychotics: increase risk of extrapyramidal reactions.
  • MAO inhibitors: may precipitate hypertensive crises.
  • CNS depressants: enhance sedation and respiratory depression.
  • CYP450 inhibitors: raise plasma concentrations of metoclopramide.
  • QT‑prolonging agents: elevate the chance of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Opioids: additive gastrointestinal effects and constipation.
  • Anticholinergics: may diminish metoclopramide’s pro‑kinetic action.
  • Alcohol: can intensify central nervous system depression.
  • Digoxin: possible alteration of serum levels.
  • SSRIs: potential for serotonin syndrome when combined.

Frequently Asked Questions

Metoclopramida Accord is prescribed for the relief of nausea and vomiting, for improving gastric emptying in gastroparesis, and for reducing symptoms of gastro‑oesophageal reflux disease by enhancing lower oesophageal sphincter tone.

Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone, which suppresses the vomiting reflex, and it stimulates acetylcholine release in the gastrointestinal tract, increasing smooth‑muscle contractility and promoting faster gastric emptying.

The appropriate dose of Metoclopramida Accord is determined by the prescribing healthcare professional based on the patient’s condition, age, renal function and response to therapy. Dosage instructions are provided on the prescription label.

The safety of metoclopramide in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many anti‑emetics because it also has pro‑kinetic activity, enhancing gastric motility, whereas agents such as ondansetron act solely on serotonin receptors. This dual action can be advantageous in conditions where delayed gastric emptying contributes to nausea.

Metoclopramida Accord should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf‑life.

The medication is taken orally, usually with a glass of water. It may be administered with or without food, but consistent timing relative to meals can help reduce gastrointestinal side effects. Follow the prescribing clinician’s instructions for frequency and duration.

Serious risks include extrapyramidal reactions such as dystonia, tardive dyskinesia, and neuroleptic malignant syndrome. Patients should be monitored for signs of muscle rigidity, involuntary movements, fever, or severe mood changes, and the drug should be discontinued if these occur.

Metoclopramida Accord is contraindicated in individuals with known hypersensitivity to metoclopramide or any component of the formulation, and it should be avoided in patients with a history of seizure disorders, severe depression, or those taking certain interacting medications without close supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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