Product image of Metoclopramida Medinfar (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramida Medinfar

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramida Medinfar (Metoclopramide Hydrochloride)

Metoclopramide, the active ingredient in Metoclopramida Medinfar, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It is used to treat nausea, vomiting, gastroparesis, gastro‑oesophageal reflux disease and to prevent chemotherapy‑induced nausea in adult patients.
GNH India supplies Metoclopramida Medinfar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratório Medinfar - Produtos Farmacêuticos, S.A.

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Indications & Clinical Uses

Metoclopramide acts on the dopaminergic pathways that trigger nausea and affect gastrointestinal motility, making it useful for several gastrointestinal and emetic conditions.

  • Nausea and vomiting: reduces frequency and severity of acute and chronic episodes.
  • Gastroparesis: enhances gastric emptying and improves related symptoms.
  • Gastro‑oesophageal reflux disease (GERD): alleviates reflux by promoting gastric clearance.
  • Prevention of chemotherapy‑induced nausea: helps control nausea associated with anticancer treatments.

How It Works

  • Metoclopramide antagonizes peripheral and central dopamine D2 receptors, which disinhibits acetylcholine release in the gastrointestinal tract, thereby increasing motility. It also blocks dopamine receptors in the chemoreceptor trigger zone of the medulla, reducing the central perception of nausea and vomiting.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inner sense of unease or agitation.
  • Diarrhea: loose, frequent stools.
  • Headache: mild to moderate cranial pain.
  • Dizziness: sensation of light‑headedness or vertigo.
  • Fatigue: reduced energy levels.

Serious or Rare Side Effects

  • Tardive dyskinesia: involuntary, repetitive movements, potentially irreversible.
  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Severe depression or suicidal thoughts.
  • Seizures: convulsive episodes.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Hyperprolactinemia: elevated prolactin causing galactorrhea or menstrual disturbances.

Precautions & Warnings

Before prescribing Metoclopramide, clinicians should consider several safety factors.

  • Renal or hepatic impairment: adjust use and monitor function.
  • Extrapyramidal symptoms: watch for muscle rigidity or tremor.
  • Use lowest effective dose: minimize risk of movement disorders.
  • Known hypersensitivity: avoid in patients with prior allergic reactions.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Metoclopramide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): may increase risk of extrapyramidal effects.
  • MAO inhibitors: can potentiate central nervous system side effects.
  • CNS depressants (opioids, benzodiazepines): may enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome.
  • Antihistamines: can augment drowsiness.
  • Anticholinergic agents: may reduce pro‑kinetic efficacy.
  • Alcohol: can intensify dizziness and sedation.

Frequently Asked Questions

Metoclopramida Medinfar, containing metoclopramide, is prescribed to manage nausea and vomiting, treat gastroparesis, alleviate symptoms of gastro‑oesophageal reflux disease, and prevent nausea associated with chemotherapy. It works by enhancing gastrointestinal motility and blocking dopamine receptors that trigger nausea.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the sensation of nausea. It also antagonizes peripheral dopamine receptors, which increases acetylcholine activity in the gut, thereby stimulating gastric emptying and improving overall gastrointestinal motility.

The specific dose of Metoclopramida Medinfar is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and response to therapy. Healthcare professionals should follow local prescribing guidelines and adjust the regimen as needed.

Safety data for metoclopramide in pregnancy are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from other antiemetics such as ondansetron, which primarily blocks serotonin receptors. Metoclopramide’s dopamine antagonism provides both anti‑nausea and pro‑kinetic effects, making it useful for conditions involving delayed gastric emptying, whereas serotonin antagonists lack the pro‑kinetic benefit.

Metoclopramida Medinfar should be stored at room temperature, below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

The product is supplied as oral tablets and is taken by mouth with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include the development of tardive dyskinesia, a potentially irreversible movement disorder, and neuroleptic malignant syndrome, a life‑threatening condition characterized by fever, muscle rigidity and autonomic instability. Patients should be monitored for early signs of these reactions.

Metoclopramida Medinfar is contraindicated in individuals with known hypersensitivity to metoclopramide or any component of the formulation, and in patients with a history of pheochromocytoma or seizure disorders unless benefits outweigh risks. It should also be avoided in patients taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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