Product image of Metoclopramida Medinfar (Metoclopramide Hydrochloride Anhydrous) supplied by GNH India

Metoclopramida Medinfar

Active Ingredient:
Metoclopramide Hydrochloride Anhydrous
Origin:
EU

Metoclopramida Medinfar (Metoclopramide Hydrochloride Anhydrous)

Metoclopramide, the active ingredient in Metoclopramida Medinfar, is a dopamine antagonist presented as an oral dosage form for oral use. It is employed to treat nausea and vomiting, gastroparesis, gastro‑esophageal reflux disease, and postoperative nausea and vomiting in adult patients.

GNH India supplies Metoclopramida Medinfar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Its supply chain supports timely delivery and traceability across multiple continents.

Manufacturer / TM Owner

Laboratório Medinfar - Produtos Farmacêuticos, S.A.

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Indications & Clinical Uses

  • Metoclopramide acts on the dopaminergic pathways that regulate nausea, vomiting and gastrointestinal motility.
  • Nausea and vomiting: reduces frequency and severity of acute and chronic nausea episodes.
  • Gastroparesis: enhances gastric emptying and alleviates related symptoms.
  • Gastro‑esophageal reflux disease (GERD): improves lower esophageal sphincter tone and reduces reflux episodes.
  • Post‑operative nausea and vomiting: prevents nausea and vomiting after surgical procedures.

How It Works

  • Metoclopramide exerts its effect by antagonizing dopamine D2 receptors in the chemoreceptor trigger zone of the brain and in the gastrointestinal tract. This blockade enhances the release of acetylcholine, promoting gastric motility and accelerating gastric emptying, while also diminishing the central stimulation of nausea and vomiting pathways. The combined central and peripheral actions result in a net antiemetic and prokinetic effect, useful in conditions where delayed gastric emptying contributes to symptomatology.

Side Effects

Metoclopramide may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Diarrhea
  • Headache

Serious or Rare Side Effects

  • Extrapyramidal reactions (e.g., dystonia, akathisia)
  • Tardive dyskinesia with prolonged use
  • Neuroleptic malignant syndrome
  • Severe allergic reactions (anaphylaxis)

Precautions & Warnings

When prescribing Metoclopramide, clinicians should consider several safety precautions to minimize risk.

  • Assess renal function: adjust dose or avoid use in severe impairment.
  • Monitor for extrapyramidal symptoms: watch for involuntary movements and discontinue if they occur.
  • Evaluate for depression or suicidal thoughts: discontinue if severe mood changes develop.
  • Use with caution in gastrointestinal obstruction: may exacerbate blockage.
  • Avoid in known hypersensitivity: discontinue at first sign of allergic reaction.
  • Store at room temperature: keep in the original packaging, protect from moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive central dopamine blockade increasing extrapyramidal risk.
  • MAO inhibitors: risk of hypertensive crisis and serotonin syndrome.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increase metoclopramide plasma levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: may reduce prokinetic effect.
  • SSRIs: potential for serotonin syndrome when combined.
  • Diuretics: may affect electrolyte balance and gastric motility.

Frequently Asked Questions

Metoclopramida Medinfar contains metoclopramide, an antiemetic and gastroprokinetic agent. It is prescribed to relieve nausea and vomiting, to treat gastroparesis by speeding gastric emptying, to manage gastro‑esophageal reflux disease, and to prevent postoperative nausea and vomiting in adult patients.

Metoclopramide works by blocking dopamine D2 receptors in the brain’s chemoreceptor trigger zone and in the gastrointestinal tract. This blockade increases acetylcholine release, which stimulates smooth‑muscle contraction, enhances gastric motility, and reduces the central signaling that triggers nausea and vomiting.

The exact dose of Metoclopramida Medinfar is set by the prescribing clinician. Dosage depends on the specific indication, the patient’s age, renal function, and overall clinical response. The prescriber tailors the regimen to achieve optimal symptom control while minimizing side effects.

Safety data for metoclopramide in pregnancy and lactation are limited. The drug should only be used when the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss alternatives when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. The sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with serotonin‑type antiemetics such as ondansetron, metoclopramide adds a prokinetic effect by stimulating gastric motility. This makes it useful for conditions involving delayed gastric emptying. However, it carries a higher risk of extrapyramidal side effects, so clinicians weigh the benefit‑risk profile based on the patient’s condition.

Metoclopramida Medinfar should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The medication is taken orally. Patients should swallow the tablet whole with a glass of water. It may be taken with or without food, although taking it with meals can reduce gastrointestinal discomfort in some individuals.

Serious adverse reactions include extrapyramidal symptoms such as dystonia or akathisia, tardive dyskinesia with long‑term use, and neuroleptic malignant syndrome, a rare but life‑threatening condition. Prompt medical attention is required if any of these symptoms develop.

Metoclopramida Medinfar should be avoided in patients with known hypersensitivity to metoclopramide, in those with gastrointestinal obstruction or perforation, and in individuals with pheochromocytoma, seizure disorders, or severe renal impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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