Product image of Metoclopramide Accord (Metoclopramide Hydrochloride Anhydrous) supplied by GNH India

Metoclopramide Accord

Active Ingredient:
Metoclopramide Hydrochloride Anhydrous
Origin:
EU

Metoclopramide Accord (Metoclopramide Hydrochloride Anhydrous)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramide Accord, is a dopamine antagonist (antiemetic, gastro‑prokinetic) presented as an oral dosage form for oral use. It is employed to control nausea, vomiting and to improve gastric emptying in a variety of clinical settings.
GNH India supplies Metoclopramide Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Metoclopramide Accord acts on dopamine pathways to manage several gastrointestinal and emetic conditions.

  • Nausea and vomiting: reduces episodes by blocking dopamine receptors in the chemoreceptor trigger zone.
  • Post‑operative nausea and vomiting: prevents and treats nausea after surgical procedures.
  • Chemotherapy‑induced nausea and vomiting: mitigates emesis associated with cytotoxic drugs.
  • Gastroparesis: accelerates gastric emptying and improves stomach motility.
  • Gastro‑oesophageal reflux disease (GERD) adjunct: enhances reflux control when used with standard therapy.

How It Works

  • Metoclopramide Hydrochloride selectively antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the central stimulus for nausea and vomiting. It also blocks peripheral D2 receptors in the gastrointestinal tract, increasing acetylcholine release, which promotes coordinated upper GI smooth‑muscle contractions and accelerates gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild sedation occurring shortly after dosing.
  • Restlessness or akathisia: feeling of inner tension or inability to stay still.
  • Diarrhea: loose stools due to increased GI motility.
  • Headache: transient cranial discomfort.

Serious or Rare Side Effects

  • Tardive dyskinesia: irreversible involuntary movements with prolonged use.
  • Neuroleptic malignant syndrome: life‑threatening hyperthermia and muscle rigidity.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust use in severe impairment.
  • Monitor for extrapyramidal symptoms: watch for involuntary movements or rigidity.
  • Avoid in patients with known hypersensitivity: discontinue if allergic reaction occurs.
  • Use caution in pregnancy: limited data, benefits must outweigh potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive dopamine blockade may worsen extrapyramidal effects.
  • CYP2D6 inhibitors (e.g., fluoxetine): increase metoclopramide plasma concentrations.
  • Anticholinergic agents: may mask early signs of extrapyramidal reactions.

Moderate Interactions (Monitor Closely)

  • Opioids: may enhance anti‑nausea benefit but increase sedation risk.
  • Macrolide antibiotics (e.g., erythromycin): synergistic increase in gastrointestinal motility.
  • Diuretics: potential for electrolyte disturbances when combined with increased GI activity.

Frequently Asked Questions

Metoclopramide Accord is prescribed to treat nausea and vomiting from various causes, including post‑operative and chemotherapy‑induced emesis, as well as to improve gastric emptying in gastroparesis and to support therapy for gastro‑oesophageal reflux disease.

The drug blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the signal that triggers nausea. It also blocks peripheral D2 receptors, enhancing acetylcholine release, which stimulates coordinated upper‑GI muscle contractions and speeds gastric emptying.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Metoclopramide in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from serotonin‑type antiemetics (e.g., ondansetron) by primarily targeting dopamine receptors and also offering gastro‑prokinetic activity. This dual action makes it useful for conditions where enhanced gastric motility is desired, whereas other agents may lack this effect.

Store at room temperature: keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Metoclopramide Accord is taken orally, usually as a tablet, with or without food as directed by the prescriber. The exact administration instructions, including timing relative to meals, should follow the healthcare provider’s guidance.

The most serious risks include the development of tardive dyskinesia, a potentially irreversible movement disorder, and neuroleptic malignant syndrome, a rare but life‑threatening condition characterized by high fever, muscle rigidity and autonomic instability.

Patients with known hypersensitivity to metoclopramide or any component of the formulation, those with a history of tardive dyskinesia, and individuals taking certain antipsychotics that may cause excessive dopamine blockade should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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