Product image of Metoclopramide Basi (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramide Basi

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramide Basi (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride Monohydrate, the active ingredient in Metoclopramide Basi, is a dopamine D2 receptor antagonist presented as an injectable solution for intramuscular and intravenous use. It is employed to control nausea and vomiting and to enhance gastrointestinal motility in adult patients.
GNH India supplies Metoclopramide Basi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metoclopramide is an anti‑emetic that acts on the chemoreceptor trigger zone and gastrointestinal tract.

  • Nausea and vomiting (including postoperative and chemotherapy‑induced): reduces the frequency and severity of episodes.
  • Gastroparesis: accelerates gastric emptying and improves related symptoms.
  • Migraine-associated nausea: alleviates nausea accompanying migraine attacks.
  • Diagnostic procedures requiring gastric emptying: facilitates timely completion of studies.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the emetic signal. It also blocks serotonin 5‑HT3 receptors and enhances acetylcholine release in the myenteric plexus, which increases gastrointestinal smooth‑muscle tone and promotes coordinated peristalsis, thereby exerting both anti‑emetic and pro‑kinetic actions.

Side Effects

Metoclopramide may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness or fatigue.
  • Restlessness or akathisia.
  • Dry mouth.
  • Diarrhea or abdominal cramping.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Tardive dyskinesia (involuntary movements).
  • Extrapyramidal symptoms (e.g., dystonia, parkinsonism).
  • Neuroleptic malignant syndrome.
  • Severe allergic reactions (anaphylaxis, skin rash).
  • Depression or suicidal ideation.
  • Seizures.

Precautions & Warnings

Metoclopramide requires careful monitoring in several clinical situations.

  • Extrapyramidal monitoring: watch for muscle rigidity, tremor, or abnormal movements.
  • Depression risk: assess for mood changes, especially in patients with a history of depression.
  • Parkinson's disease: avoid use as it may worsen motor symptoms.
  • Renal impairment: dose adjustment may be needed in patients with reduced kidney function.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other dopamine antagonists: additive extrapyramidal effects.
  • CNS depressants (e.g., benzodiazepines, opioids): enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Opioid analgesics: may increase risk of constipation and reduced gastric motility.
  • Anticholinergic agents: may diminish pro‑kinetic effect.
  • Serotonergic drugs (SSRIs, SNRIs, triptans): potential for serotonin syndrome.
  • Alcohol: may potentiate central nervous system depression.

Frequently Asked Questions

Metoclopramide Basi is used to prevent and treat nausea and vomiting associated with surgery, chemotherapy, and certain gastrointestinal disorders. It also promotes gastric emptying in conditions such as gastroparesis, helping to relieve related symptoms.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the signal that triggers nausea. It also enhances acetylcholine release in the gut, increasing smooth‑muscle tone and coordinated peristalsis, which improves gastric motility.

The dose of Metoclopramide Basi is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal function. The prescriber will select the appropriate strength, route, and frequency for each individual case.

Metoclopramide should be used in pregnancy or while breastfeeding only if the potential benefit outweighs any possible risk to the fetus or infant. Healthcare providers evaluate each situation individually and discuss safety considerations with the patient.

To order Metoclopramide Basi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metoclopramide differs from many anti‑emetics by offering both anti‑emetic and pro‑kinetic actions. Unlike pure serotonin antagonists such as ondansetron, it also stimulates gastric motility, making it useful for conditions where delayed gastric emptying contributes to symptoms.

Metoclopramide Basi should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and potency.

Metoclopramide Basi is administered by a healthcare professional via intramuscular or intravenous injection. The exact route, dosage, and infusion rate are determined by the prescriber according to the clinical indication and patient-specific factors.

The most serious risks include tardive dyskinesia, a potentially irreversible movement disorder, and extrapyramidal symptoms such as dystonia or parkinsonism. Neuroleptic malignant syndrome and severe allergic reactions are also rare but critical adverse events that require immediate medical attention.

Metoclopramide Basi is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, and individuals with a history of severe extrapyramidal reactions. Caution is advised in patients with Parkinson’s disease, uncontrolled epilepsy, or severe depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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