Product image of Metoclopramide Chelonia Healthcare (Metoclopramide Hydrochloride Bp) supplied by GNH India

Metoclopramide Chelonia Healthcare

Active Ingredient:
Metoclopramide Hydrochloride Bp
Origin:
EU

Metoclopramide Chelonia Healthcare (Metoclopramide Hydrochloride Bp)

Metoclopramide, the active ingredient in Metoclopramide Chelonia Healthcare, is a dopamine antagonist (antiemetic) presented as an oral dosage form for oral use. It is employed to alleviate nausea and vomiting associated with postoperative recovery, chemotherapy, and gastrointestinal motility disorders such as gastroparesis, functional dyspepsia, and reflux esophagitis.

GNH India supplies Metoclopramide Chelonia Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier, providing EU‑origin medication to hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chelonia Healthcare Limited

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Indications & Clinical Uses

Metoclopramide is used to manage conditions related to nausea, vomiting and delayed gastric emptying.

  • Nausea and vomiting: reduces frequency and severity of nausea and vomiting in postoperative, chemotherapy‑induced and other causes.
  • Gastroparesis: enhances gastric motility and relieves symptoms of delayed gastric emptying.
  • Functional dyspepsia: alleviates upper abdominal discomfort, early satiety and bloating.
  • Reflux esophagitis: decreases reflux episodes by promoting faster gastric emptying.

How It Works

  • Metoclopramide acts as a competitive antagonist at dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract, while also blocking 5‑HT3 receptors and exerting weak cholinergic activity. This combined action increases gastric motility, accelerates gastric emptying, and diminishes the central stimulation of nausea and vomiting pathways.

Side Effects

Metoclopramide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Restlessness or agitation
  • Diarrhea
  • Dry mouth
  • Headache

Serious or Rare Side Effects

  • Extrapyramidal symptoms, including tardive dyskinesia
  • Neuroleptic malignant syndrome
  • Severe depression or suicidal thoughts
  • Seizures
  • Anaphylactic or severe allergic reactions
  • Cardiac arrhythmias or QT prolongation

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess neurological history: patients with Parkinson’s disease or seizure disorders may be at higher risk.
  • Monitor for signs of depression or suicidal thoughts: report promptly.
  • Avoid prolonged use: limit to 12 days for nausea to reduce risk of tardive dyskinesia.
  • Use caution in renal impairment: dose adjustment may be required.
  • Pregnancy and lactation: consult a healthcare provider as safety data are limited.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Metoclopramide can interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Co‑administration with other dopamine antagonists: additive extrapyramidal effects.
  • Combination with serotonergic agents (e.g., SSRIs, triptans): increased risk of serotonin syndrome.
  • Use with anticholinergic drugs: may enhance anticholinergic burden.
  • Interaction with CYP2D6 inhibitors (e.g., fluoxetine): increased metoclopramide plasma levels.

Moderate Interactions (Monitor Closely)

  • Concurrent use with CNS depressants (e.g., benzodiazepines, alcohol): may increase sedation.
  • Combination with other anti‑emetics such as ondansetron: possible additive anti‑emetic effect.
  • Use with drugs that prolong QT interval: monitor cardiac rhythm.

Frequently Asked Questions

Metoclopramide Chelonia Healthcare is used to treat nausea and vomiting from postoperative recovery, chemotherapy, and other causes, as well as to improve gastric emptying in conditions such as gastroparesis, functional dyspepsia, and reflux esophagitis.

Metoclopramide works by blocking dopamine D2 receptors in the brain’s chemoreceptor trigger zone and the gastrointestinal tract, while also antagonising 5‑HT3 receptors and providing weak cholinergic stimulation. This combination speeds gastric motility and reduces the central drive for nausea and vomiting.

The appropriate dose of metoclopramide is determined by the prescribing healthcare professional based on the specific indication, patient age, renal function and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for metoclopramide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many anti‑emetics by acting as a dopamine D2 antagonist with additional 5‑HT3 and cholinergic activity, making it useful for both nausea control and gastric motility. Other agents, such as ondansetron, primarily target serotonin receptors and do not enhance gastric emptying.

Metoclopramide Chelonia Healthcare should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture. No refrigeration is required for this oral formulation.

Metoclopramide is administered orally, typically as a tablet or liquid formulation, and should be taken with or without food as directed by the prescriber. The exact method of administration depends on the specific product format supplied.

Serious risks include extrapyramidal reactions such as tardive dyskinesia, neuroleptic malignant syndrome, severe depression or suicidal thoughts, seizures, anaphylactic reactions, and cardiac arrhythmias. Patients should be monitored closely for any of these events.

Metoclopramide should be avoided in patients with known hypersensitivity to the drug, those with a history of severe extrapyramidal disorders, uncontrolled epilepsy, or in individuals taking MAO inhibitors. It is also contraindicated in patients with gastrointestinal obstruction or perforation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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