Product image of Metoclopramide Crescent Pharma (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramide Crescent Pharma

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramide Crescent Pharma (Metoclopramide Hydrochloride)

Metoclopramide, the active ingredient in Metoclopramide Crescent Pharma, is a dopamine antagonist presented as an oral tablet for oral use. It treats nausea, vomiting, gastroparesis, gastro‑oesophageal reflux disease and migraine‑associated nausea in adults.

GNH India supplies Metoclopramide Crescent Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Crescent Pharma Limited

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Indications & Clinical Uses

Metoclopramide is used to manage conditions related to nausea, vomiting and delayed gastric emptying.

  • Nausea and vomiting: alleviates acute and chemotherapy‑induced nausea and vomiting.
  • Gastroparesis: improves gastric emptying and reduces symptoms in diabetic or idiopathic gastroparesis.
  • Gastro‑oesophageal reflux disease (GERD): reduces reflux episodes by enhancing gastric motility.
  • Migraine‑associated nausea: lessens nausea accompanying migraine attacks.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the central stimulus for nausea and vomiting. It also blocks presynaptic D2 receptors in the gastrointestinal tract, increasing acetylcholine release, which enhances gastric smooth‑muscle contractility and accelerates gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness: mild sedation or fatigue.
  • Restlessness: feeling of inner tension or agitation.
  • Diarrhea: loose stools or increased bowel movements.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity, tremor, or dystonia.
  • Tardive dyskinesia: persistent involuntary movements with long‑term use.
  • Neuroleptic malignant syndrome: rare life‑threatening reaction with fever and muscle rigidity.

Precautions & Warnings

Before prescribing Metoclopramide, clinicians should consider several safety precautions.

  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • History of movement disorders: avoid in patients with Parkinson’s disease or prior extrapyramidal reactions.
  • Elderly patients: use cautiously due to increased risk of central nervous system effects.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as safety data are limited.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): may reduce antiemetic effect and increase extrapyramidal risk.
  • MAO inhibitors: can potentiate hypertensive reactions.
  • CYP2D6 substrates (e.g., codeine): may increase plasma levels of the substrate.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Digoxin: may increase digoxin serum concentrations.
  • Anticholinergic agents: may diminish pro‑kinetic effect.

Frequently Asked Questions

Metoclopramide Crescent Pharma is prescribed to relieve nausea and vomiting, to treat gastroparesis by improving gastric emptying, to manage gastro‑oesophageal reflux disease, and to reduce nausea that accompanies migraine attacks. It is used in adult patients under medical supervision.

Metoclopramide works by blocking dopamine D2 receptors in the brain’s chemoreceptor trigger zone, which reduces the signal that triggers nausea and vomiting. In the gastrointestinal tract it blocks presynaptic D2 receptors, leading to increased acetylcholine release and enhanced gastric motility.

The dosage of Metoclopramide Crescent Pharma is determined by the prescribing clinician based on the patient’s condition, age, renal function and other factors. The prescriber will set the appropriate strength, frequency and duration of therapy.

Safety data for metoclopramide in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide belongs to the dopamine antagonist class, whereas many other antiemetics are serotonin (5‑HT3) antagonists or antihistamines. Metoclopramide also has pro‑kinetic activity, which can be advantageous for gastroparesis, but it carries a higher risk of extrapyramidal side effects compared with some alternatives.

Metoclopramide Crescent Pharma tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

The medication is supplied as oral tablets and is taken by mouth with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include extrapyramidal reactions such as dystonia or tardive dyskinesia, especially with prolonged use, and rare events like neuroleptic malignant syndrome. Patients should be monitored for any abnormal movements, muscle rigidity or fever and seek immediate medical attention if these occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, in those with a history of Parkinson’s disease or other movement disorders, and in individuals taking monoamine oxidase inhibitors. It should also be used with caution in severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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