Metoclopramide G.L. Pharma (Metoclopramide Hydrochloride)

Metoclopramide works by competitively antagonising dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract, which reduces nausea signals and accelerates gastric emptying. It also weakly blocks 5‑HT3 receptors, adding to its anti‑nausea effect.

The appropriate dose of Metoclopramide is determined by the prescribing clinician based on the specific indication, patient characteristics, and the chosen route of administration (intravenous or intramuscular). Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Metoclopramide in pregnancy are limited and it is classified as a pregnancy category unknown. It should only be used when the potential benefit justifies any possible risk to the fetus. Caution is also advised during breastfeeding, and the prescriber should evaluate the risk‑benefit balance.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with 5‑HT3 antagonists such as ondansetron, Metoclopramide not only blocks dopamine receptors but also promotes gastric motility, making it useful when delayed gastric emptying contributes to symptoms. Its side‑effect profile differs, with a higher risk of extrapyramidal reactions, whereas ondansetron is generally better tolerated neurologically.

Metoclopramide should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light. Do not freeze or expose it to extreme temperatures to maintain stability.

Metoclopramide is supplied as a sterile injectable solution and can be administered by intramuscular injection or intravenous infusion. The exact route, rate, and duration are determined by the healthcare professional based on the clinical situation and patient needs.

Serious risks include extrapyramidal symptoms such as dystonia or parkinsonism, tardive dyskinesia with long‑term use, neuroleptic malignant syndrome, severe allergic reactions, and the emergence of depression or suicidal thoughts. Immediate medical attention is required if any of these events occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, uncontrolled hypertension, seizure disorders, or severe depression. Caution is advised in individuals with Parkinson’s disease, the elderly, and patients with significant renal or hepatic impairment.