Product image of Metoclopramide Hydrochloride Bristol Laboratories (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramide Hydrochloride Bristol Laboratories

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramide Hydrochloride Bristol Laboratories (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramide Hydrochloride Bristol Laboratories, is a dopamine D2 receptor antagonist presented as an oral formulation for systemic use. It treats nausea, vomiting, gastroparesis and gastro‑oesophageal reflux disease in adult patients.

GNH India supplies Metoclopramide Hydrochloride Bristol Laboratories as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bristol Laboratories Limited

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Indications & Clinical Uses

Metoclopramide Hydrochloride acts on the central chemoreceptor trigger zone and enhances gastrointestinal motility, making it useful for several gastrointestinal disorders.

  • Nausea and vomiting: reduces episodes by blocking dopamine receptors in the chemoreceptor trigger zone.
  • Gastroparesis: accelerates gastric emptying through increased acetylcholine release in the gut.
  • Gastro‑oesophageal reflux disease (GERD): improves lower‑esophageal sphincter tone and gastric motility, helping to lessen reflux symptoms.

How It Works

  • Metoclopramide Hydrochloride antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the emetic signal to the brain. Concurrently, it stimulates muscarinic receptors in the gastrointestinal tract, increasing acetylcholine release, which promotes coordinated smooth‑muscle contractions and accelerates gastric emptying.

Side Effects

Metoclopramide Hydrochloride may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Restlessness or akathisia
  • Diarrhoea
  • Constipation
  • Headache

Serious or Rare Side Effects

  • Tardive dyskinesia (involuntary movements)
  • Neuroleptic malignant syndrome
  • Severe depression or suicidal thoughts
  • Seizures
  • Anaphylactic or severe allergic reactions
  • Hyperprolactinemia with galactorrhoea

Precautions & Warnings

Before prescribing Metoclopramide Hydrochloride, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Breastfeeding: unknown excretion; consider alternative therapy.
  • Elderly patients: higher susceptibility to extrapyramidal symptoms; monitor closely.
  • Gastrointestinal obstruction: use with caution as pro‑kinetic effect may be limited.
  • Concomitant CNS depressants: may enhance sedation and respiratory depression.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metoclopramide Hydrochloride can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce the pro‑kinetic effect.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increase plasma concentrations of metoclopramide.
  • Other dopamine antagonists: additive risk of extrapyramidal symptoms.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., alcohol, benzodiazepines): enhanced sedation.
  • MAO inhibitors: risk of hypertensive reactions.

Frequently Asked Questions

Metoclopramide Hydrochloride is prescribed to manage nausea and vomiting, to treat gastroparesis by enhancing gastric emptying, and to alleviate symptoms of gastro‑oesophageal reflux disease through its pro‑kinetic and anti‑emetic actions.

The drug blocks dopamine D2 receptors in the chemoreceptor trigger zone, reducing the brain’s emetic response, while simultaneously stimulating acetylcholine release in the gastrointestinal tract, which promotes coordinated smooth‑muscle contractions and speeds gastric emptying.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Dosage regimens are not standardized and should follow the prescriber’s instructions.

Safety data for Metoclopramide in pregnancy are limited, and it is classified as a precautionary use. It is excreted in breast milk, so breastfeeding mothers should discuss alternatives with their healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike antihistamines or serotonin antagonists, Metoclopramide primarily blocks dopamine receptors and also has pro‑kinetic activity, making it useful for both nausea control and gastric motility disorders. Its dual action distinguishes it from agents that act solely on histamine or serotonin pathways.

Store the oral product at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain stability and potency.

Metoclopramide Hydrochloride is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious adverse effects include tardive dyskinesia, neuroleptic malignant syndrome, severe depression or suicidal thoughts, seizures, and allergic reactions such as anaphylaxis. Patients should be monitored for any new or worsening neurological or psychiatric symptoms.

Patients with known hypersensitivity to metoclopramide, those with pheochromocytoma, uncontrolled epilepsy, severe depression, or a history of extrapyramidal disorders should avoid the drug. It is also contraindicated in individuals with gastrointestinal obstruction or perforation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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