Product image of Metoclopramide “medical Valley” (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramide “medical Valley”

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramide “medical Valley” (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide, the active ingredient in Metoclopramide “medical Valley”, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is employed to relieve nausea, vomiting and to improve gastric emptying in patients with gastroparesis or reflux disease.

GNH India supplies Metoclopramide “medical Valley” as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

Metoclopramide is a prokinetic and anti‑emetic agent that acts on the gastrointestinal tract and the chemoreceptor trigger zone.

  • Nausea and vomiting: reduces episodes of acute and chemotherapy‑induced nausea.
  • Gastroparesis: enhances gastric motility to improve stomach emptying.
  • Gastroesophageal reflux disease: decreases reflux episodes by promoting gastric clearance.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the vomiting reflex, and stimulates acetylcholine release in the gastrointestinal wall, which increases smooth‑muscle contractility and accelerates gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inner sense of agitation or inability to stay still.
  • Diarrhea: loose, watery stools.
  • Dry mouth: reduced salivation.
  • Headache: mild to moderate head pain.
  • Dystonia (especially in young adults): involuntary muscle contractions.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: severe movement disorders such as Parkinsonism.
  • Tardive dyskinesia: persistent involuntary facial movements with long‑term use.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction with fever and rigidity.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Cardiac arrhythmias: irregular heartbeats in susceptible individuals.

Precautions & Warnings

Before prescribing Metoclopramide, clinicians should consider several safety aspects.

  • Contraindication: avoid in patients with known hypersensitivity to metoclopramide.
  • Neurological disorders: use cautiously in individuals with Parkinson's disease or seizure disorders.
  • Pregnancy: assess risk versus benefit; data are limited.
  • Breastfeeding: consider potential drug transfer to infant.
  • Elderly patients: monitor closely for extrapyramidal effects.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Metoclopramide can alter the activity of several co‑administered medicines.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): additive extrapyramidal effects.
  • CYP2D6 substrates (e.g., codeine): reduced analgesic conversion.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Anticholinergic drugs (e.g., atropine): may diminish pro‑kinetic effect.
  • Digoxin: possible increase in serum levels.
  • Antihistamines: may counteract anti‑emetic action.

Frequently Asked Questions

Metoclopramide “medical Valley” is indicated for the treatment of nausea and vomiting, for managing gastroparesis by enhancing gastric emptying, and for reducing symptoms of gastro‑oesophageal reflux disease through its pro‑kinetic action.

Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone, which suppresses the vomiting reflex, and it stimulates acetylcholine release in the gut wall, increasing smooth‑muscle contractions and promoting faster gastric emptying.

The appropriate dose is determined by the prescribing clinician based on the patient’s condition, age, renal function and other clinical factors. Dosage regimens are individualized and should follow local prescribing guidelines.

Safety data for Metoclopramide in pregnancy are limited, so the drug should only be used when the potential benefit justifies any possible risk to the fetus. It is excreted in breast milk; therefore, caution is advised for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many anti‑emetics such as ondansetron, which primarily block serotonin receptors. Metoclopramide’s dopamine antagonism and pro‑kinetic activity make it useful for both nausea control and gastric motility, whereas serotonin antagonists lack the latter effect.

The product should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in a humid environment or expose the tablets to excessive heat.

Metoclopramide “medical Valley” is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless a prescriber provides an alternative administration instruction.

The most serious adverse reactions include extrapyramidal symptoms such as dystonia or Parkinson‑like features, tardive dyskinesia with long‑term use, and rare cases of neuroleptic malignant syndrome. Prompt medical attention is required if these symptoms appear.

Patients with known hypersensitivity to metoclopramide, those with a history of severe extrapyramidal reactions, and individuals taking monoamine oxidase inhibitors should avoid this medication. Clinicians should also exercise caution in patients with epilepsy, Parkinson’s disease or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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