Product image of Metoclopramide Noridem (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramide Noridem

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramide Noridem (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide, the active ingredient in Metoclopramide Noridem, is a dopamine D2 receptor antagonist presented as an injection solution for intramuscular and intravenous use. It treats nausea and vomiting, including postoperative and chemotherapy‑induced, and facilitates gastric emptying in conditions such as gastroparesis.

GNH India supplies Metoclopramide Noridem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Metoclopramide Noridem acts on dopamine pathways to control nausea, vomiting and gastric motility.

  • Nausea and vomiting: reduces frequency and severity of episodes in various clinical settings.
  • Postoperative nausea and vomiting: prevents and treats nausea after surgical procedures.
  • Chemotherapy‑induced nausea and vomiting: controls acute and delayed phases of treatment‑related emesis.
  • Gastroparesis: enhances gastric emptying and alleviates related symptoms.
  • Pre‑endoscopic procedures: facilitates gastric emptying to improve procedural tolerance.

How It Works

  • Metoclopramide competitively blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, while also antagonizing serotonin 5‑HT3 receptors and exhibiting anticholinergic activity. This combined action increases gastric motility, accelerates gastric emptying, and suppresses central and peripheral pathways that trigger nausea and vomiting.

Side Effects

Metoclopramide Noridem may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: mild sedation that may affect alertness.
  • Fatigue: reduced energy levels during treatment.
  • Diarrhea: loose stools occurring after administration.
  • Restlessness: feeling of inner tension or agitation.

Serious or Rare Side Effects

  • Extrapyramidal reactions: muscle rigidity, tremor, or dystonia.
  • Tardive dyskinesia: involuntary movements with prolonged use.
  • Neuroleptic malignant syndrome: high fever with severe muscle rigidity.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.

Precautions & Warnings

Before using Metoclopramide Noridem, consider the following precautions.

  • Assess patient history: check for prior extrapyramidal reactions or movement disorders.
  • Monitor for depression: observe mood changes during therapy.
  • Use caution in renal impairment: dose may need adjustment based on kidney function.
  • Avoid in patients with known hypersensitivity to metoclopramide.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Metoclopramide Noridem can interact with several medicines.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce pro‑kinetic effect.
  • CYP2D6 inhibitors (e.g., fluoxetine): increase plasma levels of metoclopramide.
  • Dopamine agonists (e.g., levodopa): antagonize therapeutic effect.
  • MAO inhibitors: risk of hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Sedatives: additive central nervous system depression.
  • Alcohol: may enhance drowsiness.
  • Other antiemetics (e.g., ondansetron): possible additive effect on QT interval.

Frequently Asked Questions

Metoclopramide Noridem is an injectable formulation of metoclopramide used to manage nausea and vomiting, including postoperative and chemotherapy‑induced episodes, and to promote gastric emptying in gastroparesis or before certain diagnostic and therapeutic procedures.

Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, antagonizes serotonin 5‑HT3 receptors, and exhibits anticholinergic activity. These actions together increase gastric motility and suppress the neural pathways that trigger nausea and vomiting.

The specific dose and administration schedule are determined by the prescribing clinician based on the indication, patient age, weight, renal function and clinical response. No standard dose is provided here; the prescriber sets the appropriate regimen.

Safety data are limited and the product is classified as pregnancy category unknown. It should be used only if the potential benefit justifies any potential risk to the fetus, and caution is advised during lactation.

Submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Compared with serotonin‑type 3 antagonists such as ondansetron, metoclopramide adds pro‑kinetic activity by enhancing gastric motility, but it carries a higher risk of extrapyramidal side effects. Choice depends on the clinical scenario, patient tolerance and the desired combination of anti‑emetic and pro‑kinetic effects.

Store at ambient temperature, below 25 °C, in the original container, protected from light and moisture. Do not freeze or expose the product to extreme temperatures.

Metoclopramide Noridem is supplied as a sterile injection solution for intramuscular or intravenous use. Administration is performed by a qualified healthcare professional, typically as a slow IV push or IM injection, following aseptic technique.

Serious adverse reactions include extrapyramidal symptoms such as acute dystonia, tardive dyskinesia with prolonged use, neuroleptic malignant syndrome, severe hypotension and anaphylaxis. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to metoclopramide, a history of severe extrapyramidal disorders, uncontrolled epilepsy, or those receiving dopamine agonists should avoid the drug. Caution is also advised in renal impairment and in elderly patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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