Product image of Metoclopramide Noridem (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Metoclopramide Noridem

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Metoclopramide Noridem (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride Monohydrate, the active ingredient in Metoclopramide Noridem, is a dopamine antagonist (prokinetic) presented as a sterile injectable solution for intramuscular or intravenous use. It treats nausea, vomiting and gastroparesis in adults.

GNH India supplies Metoclopramide Noridem as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

  • Metoclopramide Noridem is a dopamine‑antagonist prokinetic used to manage conditions that involve nausea, vomiting or delayed gastric emptying.
  • Nausea and vomiting: reduces the frequency and severity of episodes.
  • Post‑operative nausea and vomiting: prevents and treats nausea after surgery.
  • Gastroparesis: enhances gastric motility and improves stomach emptying.
  • Migraine‑associated nausea: alleviates nausea accompanying migraine attacks.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and blocks serotonin 5‑HT3 receptors, while stimulating 5‑HT4 receptors in the gastrointestinal tract. This combined action accelerates gastric emptying, increases lower‑esophageal sphincter tone, and suppresses the central vomiting reflex, providing anti‑emetic and pro‑kinetic effects.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects

  • Drowsiness or fatigue.
  • Restlessness or akathisia.
  • Diarrhea or abdominal cramping.
  • Dizziness or headache.

Serious or Rare Side Effects

  • Tardive dyskinesia, a potentially irreversible movement disorder.
  • Neuroleptic malignant syndrome, characterized by fever and muscle rigidity.
  • Severe allergic reactions such as anaphylaxis.
  • Hyperprolactinemia leading to galactorrhea or menstrual disturbances.
  • Seizures, especially in patients with pre‑existing neurological conditions.

Precautions & Warnings

  • Before prescribing Metoclopramide Noridem, clinicians should consider several safety aspects.
  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor for extrapyramidal symptoms: watch for tremor, rigidity, or involuntary movements.
  • Use caution in patients with depression or a history of suicidal ideation.
  • Avoid in individuals with known hypersensitivity to metoclopramide or its excipients.
  • Adjust dose in elderly patients: start with the lowest effective dose.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): may increase risk of extrapyramidal reactions.
  • Monoamine‑oxidase inhibitors: can potentiate central nervous system effects.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine): may raise metoclopramide plasma levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Anticholinergic agents: may reduce pro‑kinetic effectiveness.

Frequently Asked Questions

Metoclopramide Noridem is a prescription injectable medication used to treat nausea and vomiting, prevent post‑operative nausea, manage gastroparesis, and relieve migraine‑associated nausea by enhancing gastrointestinal motility and blocking central vomiting pathways.

The drug blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone and serotonin 5‑HT3 receptors, while stimulating 5‑HT4 receptors in the gut. This dual action speeds gastric emptying and suppresses the central vomiting reflex, providing both anti‑emetic and pro‑kinetic effects.

Dosing is individualized by the prescribing clinician based on the patient’s condition, age, renal function and route of administration. The prescriber determines the appropriate amount, frequency and duration of therapy.

Metoclopramide is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but insufficient human data. It may be used during pregnancy only if clearly needed. Small amounts are excreted in breast milk; breastfeeding decisions should be made with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Compared with serotonin‑type 5‑HT3 antagonists (e.g., ondansetron), metoclopramide adds pro‑kinetic activity by stimulating gastric motility. It is generally less expensive but carries a higher risk of extrapyramidal side effects, so clinicians weigh efficacy, safety profile and patient factors when selecting therapy.

Store the injectable solution at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect from light, and avoid moisture. Do not freeze. Follow any additional handling instructions on the label.

The medication is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration technique, rate and site are determined by the prescriber and should follow aseptic procedures and local clinical guidelines.

The most serious risks include tardive dyskinesia, a potentially irreversible movement disorder, neuroleptic malignant syndrome, severe allergic reactions, seizures, and hyperprolactinemia. Patients should be monitored closely for early signs of these conditions.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, and individuals with a history of tardive dyskinesia. Caution is advised in patients with severe renal impairment, epilepsy, depression, or gastrointestinal obstruction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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