Product image of Metoclopramide Orifarm (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramide Orifarm

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramide Orifarm (Metoclopramide Hydrochloride)

Metoclopramide, the active ingredient in Metoclopramide Orifarm, is a dopamine antagonist (antiemetic, gastro‑prokinetic) presented as an oral dosage form for systemic use. It is indicated for use in patients experiencing acute or chronic nausea, for those with delayed gastric emptying, and as a prophylactic agent before chemotherapy.\n\nGNH India supplies Metoclopramide Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

  • Metoclopramide acts on the dopaminergic pathways of the gastrointestinal system and the central chemoreceptor trigger zone to control several conditions.\n\n- Nausea and vomiting: reduces frequency and severity of episodes in various settings.\n- Gastroparesis: enhances gastric emptying and relieves associated symptoms.\n- Gastro‑oesophageal reflux disease (GERD): decreases reflux episodes and improves patient comfort.\n- Chemotherapy‑induced nausea: prevents or lessens nausea associated with anticancer treatment.

How It Works

  • Metoclopramide exerts its effect by competitively blocking dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract, which diminishes nausea signaling. It also antagonizes serotonin 5‑HT3 receptors and potentiates acetylcholine release, thereby stimulating coordinated gastric motility and accelerating gastric emptying. The combined dopaminergic and serotonergic antagonism also reduces the afferent input to the vomiting centre, while the cholinergic enhancement promotes peristalsis in the upper GI tract.

Side Effects

  • Metoclopramide may cause a range of adverse reactions, which are classified by frequency and severity.\n\nCommon Side Effects:\n- Drowsiness: feeling of sleepiness or reduced alertness.\n- Fatigue: general tiredness or lack of energy.\n- Restlessness: uneasy feeling often described as akathisia.\n- Dry mouth: reduced salivation leading to throat discomfort.\n\nSerious or Rare Side Effects:\n- Extrapyramidal symptoms: involuntary muscle movements or rigidity.\n- Tardive dyskinesia: persistent, potentially irreversible facial or tongue movements.\n- Neuroleptic malignant syndrome: rare life‑threatening reaction with fever and muscle rigidity.\n- Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

  • Before prescribing Metoclopramide, clinicians should consider several precautionary measures to ensure safe use.\n\n- Assess renal and hepatic function: adjust use in patients with impairment.\n- Monitor for extrapyramidal symptoms: watch for muscle rigidity or tremor.\n- Avoid in patients with known hypersensitivity: discontinue if allergic reaction occurs.\n- Use caution in the elderly: increased susceptibility to CNS effects.\n- Limit duration of therapy: prolonged use raises risk of tardive dyskinesia.\n- Store at below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

  • Metoclopramide can interact with other medicines, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Antipsychotics (e.g., haloperidol): may counteract antiemetic effect.\n- Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive crisis.\n- Central nervous system depressants (e.g., opioids): enhance sedation and respiratory depression.\n\nModerate Interactions (Monitor Closely):\n- CYP2D6 inhibitors (e.g., fluoxetine): may raise metoclopramide plasma levels.\n- Anticholinergic agents: may reduce pro‑kinetic benefit.\n- Selective serotonin reuptake inhibitors (SSRIs): potential for additive serotonergic effects.

Frequently Asked Questions

Metoclopramide Orifarm is a prescription oral medication used to treat nausea and vomiting, to improve gastric emptying in gastroparesis, to relieve symptoms of gastro‑oesophageal reflux disease, and to prevent nausea associated with chemotherapy. It works by influencing dopamine and serotonin pathways that control the vomiting centre and gastrointestinal motility.

Metoclopramide works by competitively blocking dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract, which reduces nausea signalling. It also antagonises serotonin 5‑HT3 receptors and enhances acetylcholine release, promoting coordinated gastric contractions and faster gastric emptying.

The appropriate dose of Metoclopramide Orifarm is determined by the prescribing healthcare professional based on the specific indication, patient age, renal and hepatic function, and other clinical factors. Patients should follow the dosage instructions provided by their prescriber and pharmacist.

The safety of metoclopramide in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Metoclopramide Orifarm, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from serotonin‑type antiemetics such as ondansetron by primarily blocking dopamine D2 receptors and having pro‑kinetic activity that enhances gastric motility. It may be preferred when delayed gastric emptying is a concern, whereas ondansetron is often chosen for its selective 5‑HT3 antagonism and lower risk of extrapyramidal effects.

Metoclopramide Orifarm should be stored at temperatures below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Metoclopramide Orifarm is taken orally, usually with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include extrapyramidal symptoms such as acute dystonia, tardive dyskinesia with long‑term use, and neuroleptic malignant syndrome, a rare but life‑threatening condition. Patients should seek immediate medical attention if they experience muscle rigidity, high fever, confusion, or uncontrolled movements.

Metoclopramide is contraindicated in individuals with known hypersensitivity to the drug, in patients with pheochromocytoma, and in those with a history of severe extrapyramidal reactions. Caution is also advised for patients with gastrointestinal obstruction, perforation, or hemorrhage.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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