Product image of Metoclopramidemonohydrochloride Accord (Metoclopramide Hydrochloride Anhydrous) supplied by GNH India

Metoclopramidemonohydrochloride Accord

Active Ingredient:
Metoclopramide Hydrochloride Anhydrous
Origin:
EU

Metoclopramidemonohydrochloride Accord (Metoclopramide Hydrochloride Anhydrous)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramidemonohydrochloride Accord, is a dopamine antagonist presented as an oral tablet for oral use. It is used to treat nausea, vomiting, gastroparesis, gastro‑oesophageal reflux disease and pre‑ or post‑operative nausea in adult patients.

GNH India supplies Metoclopramidemonohydrochloride Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Metoclopramide acts on the dopaminergic and serotonergic pathways to control nausea, vomiting and gastrointestinal motility.

  • Nausea and vomiting: reduces frequency and severity of acute and chemotherapy‑induced episodes.
  • Gastroparesis: enhances gastric emptying and relieves associated symptoms.
  • Gastro‑oesophageal reflux disease (GERD): decreases reflux episodes by improving lower esophageal sphincter tone.
  • Pre‑operative and post‑operative nausea: prevents and treats nausea related to surgical procedures.

How It Works

  • Metoclopramide antagonizes peripheral and central dopamine D2 receptors, blocks serotonin 5‑HT3 receptors and acts as a 5‑HT4 receptor agonist. This combined activity increases gastrointestinal motility, accelerates gastric emptying, and suppresses the central vomiting centre, thereby reducing nausea and vomiting.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inability to stay still or calm.
  • Diarrhea: loose or frequent stools.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness or vertigo.
  • Fatigue: overall lack of energy.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Tardive dyskinesia: persistent, irreversible facial or tongue movements.
  • Neuroleptic malignant syndrome: life‑threatening fever and muscle rigidity.
  • Depression or suicidal thoughts: mood changes requiring immediate attention.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Hyperprolactinemia: elevated prolactin levels causing hormonal effects.

Precautions & Warnings

Before prescribing Metoclopramide, clinicians should consider several safety factors.

  • Pregnancy: Category B – use only if potential benefit justifies the potential risk to the fetus.
  • Renal impairment: dose adjustment may be required in patients with reduced kidney function.
  • History of movement disorders: avoid in patients with Parkinson's disease or tardive dyskinesia.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce pro‑kinetic effect.
  • CNS depressants (e.g., benzodiazepines): increased sedation risk.
  • MAO inhibitors: heightened risk of hypertensive crisis.
  • CYP2D6 inhibitors: elevated plasma levels of metoclopramide.
  • QT‑prolonging drugs: additive risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Opioids: may enhance nausea control but increase sedation.
  • Antihistamines: possible additive drowsiness.
  • SSRIs: monitor for serotonin syndrome.
  • Diabetic medications: may affect glucose control.
  • Alcohol: increased central nervous system effects.

Frequently Asked Questions

Metoclopramidemonohydrochloride Accord is prescribed to manage nausea and vomiting, treat gastroparesis, alleviate symptoms of gastro‑oesophageal reflux disease, and prevent or treat pre‑ and post‑operative nausea in adult patients.

Metoclopramide blocks dopamine D2 receptors in the chemoreceptor trigger zone and antagonizes serotonin 5‑HT3 receptors, while stimulating 5‑HT4 receptors. This combination enhances gastrointestinal motility and suppresses the central vomiting centre, reducing nausea and vomiting.

The appropriate dose of Metoclopramidemonohydrochloride Accord is determined by the prescribing clinician based on the patient’s condition, age, renal function and other individual factors. Patients should follow the prescriber’s instructions exactly.

Metoclopramide is classified as Pregnancy Category B, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy only if the potential benefit outweighs any risk. Caution is advised while breastfeeding, and a healthcare professional should evaluate the situation.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many antiemetics by combining dopamine antagonism with serotonin receptor modulation, offering both anti‑nausea and gastro‑prokinetic effects. Other agents, such as ondansetron, primarily block 5‑HT3 receptors without enhancing gastric motility, making metoclopramide useful when delayed gastric emptying is a concern.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, and avoid exposure to direct sunlight or extreme temperatures.

The medication is taken orally, usually with a glass of water. It can be administered with or without food, but patients should follow the specific instructions provided by their prescriber regarding timing relative to meals.

Serious risks include extrapyramidal symptoms such as acute dystonia, tardive dyskinesia, neuroleptic malignant syndrome, severe depression or suicidal thoughts, cardiac arrhythmias, and hyperprolactinemia. Patients should seek immediate medical attention if any of these occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, those with pheochromocytoma, and individuals with a history of severe extrapyramidal reactions or tardive dyskinesia. Caution is also advised for patients with gastrointestinal obstruction or perforation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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