Product image of Metoclopramidhydrochlorid Accord (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramidhydrochlorid Accord

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramidhydrochlorid Accord (Metoclopramide Hydrochloride)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramidhydrochlorid Accord, is a dopamine antagonist (antiemetic) presented as an oral dosage form for oral use. It is indicated for nausea and vomiting associated with chemotherapy, postoperative states, gastroparesis and as an adjunct in gastro‑oesophageal reflux disease.
GNH India supplies Metoclopramidhydrochlorid Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Metoclopramide Hydrochloride acts on the central chemoreceptor trigger zone and gastrointestinal motility to control emesis and improve gastric emptying.

  • Chemotherapy‑induced nausea and vomiting: reduces frequency and severity of episodes.
  • Postoperative nausea and vomiting: helps control symptoms after surgery.
  • Gastroparesis: enhances gastric motility and alleviates related discomfort.
  • Gastro‑oesophageal reflux disease (adjunct): supports reflux management by promoting gastric emptying.

How It Works

  • Metoclopramide Hydrochloride exerts its therapeutic effect by competitively antagonising dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract, thereby reducing nausea signals. It also blocks 5‑HT3 receptors and stimulates 5‑HT4 receptors, which together increase gastric motility and accelerate gastric emptying.

Side Effects

Metoclopramide Hydrochloride may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness
  • Fatigue
  • Restlessness or agitation
  • Diarrhoea
  • Headache
  • Dry mouth

Serious or Rare Side Effects

  • Tardive dyskinesia (involuntary movements)
  • Neuroleptic malignant syndrome
  • Severe depression or suicidal thoughts
  • Seizures
  • Allergic reactions including anaphylaxis
  • Cardiac arrhythmias

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • History of movement disorders: avoid in patients with prior tardive dyskinesia.
  • Depression or suicidal ideation: monitor mental health closely.
  • Renal impairment: dose adjustment may be required.
  • Duration of therapy: limit use to the shortest period necessary, generally not exceeding 12 weeks.
  • Concomitant dopamine‑blocking agents: assess risk of additive effects.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metoclopramide Hydrochloride can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): additive dopamine antagonism.
  • MAO inhibitors: risk of hypertensive crisis.
  • CNS depressants (opioids, benzodiazepines): increased sedation.
  • Serotonergic agents (ondansetron, SSRIs): potential serotonin syndrome.
  • CYP2D6 inhibitors (fluoxetine, paroxetine): elevated metoclopramide levels.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: may diminish pro‑kinetic effect.
  • CYP3A4 inducers (rifampin, carbamazepine): reduced efficacy.
  • NSAIDs: heightened risk of gastrointestinal irritation.
  • Diuretics: possible electrolyte disturbances.
  • Alcohol: may enhance central nervous system depression.

Frequently Asked Questions

Metoclopramidhydrochlorid Accord is prescribed for nausea and vomiting caused by chemotherapy, postoperative states, and other triggers, as well as for gastroparesis and as an adjunct therapy in gastro‑oesophageal reflux disease to improve gastric motility.

The drug blocks dopamine D2 receptors in the chemoreceptor trigger zone, reducing the brain’s nausea signals. It also antagonises 5‑HT3 receptors and stimulates 5‑HT4 receptors, which together enhance gastric emptying and further diminish nausea.

The appropriate dose is individualized by the prescribing clinician based on the patient’s condition, severity of symptoms, age, renal function and other clinical factors. No fixed regimen is provided here.

The pregnancy category for metoclopramide hydrochloride is not definitively established. Use during pregnancy or lactation should only occur when the potential benefit justifies any potential risk, and after a thorough discussion with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide primarily blocks dopamine receptors and has pro‑kinetic activity, making it useful for gastroparesis as well as nausea. Ondansetron targets serotonin 5‑HT3 receptors and lacks pro‑kinetic effects. Choice depends on the underlying cause of nausea, patient tolerance and specific clinical considerations.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight and excessive heat to maintain stability and potency.

The medication is taken orally, usually with a glass of water. It may be administered with or without food, but consistent timing with meals can help reduce gastrointestinal side effects. Follow the prescriber’s instructions for exact timing.

Serious adverse reactions include tardive dyskinesia (involuntary movements), neuroleptic malignant syndrome, severe depression or suicidal thoughts, seizures, allergic reactions such as anaphylaxis, and cardiac arrhythmias. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to metoclopramide, a history of seizure disorders, Parkinson’s disease, severe depression, or those currently receiving other dopamine‑blocking agents should avoid this medication unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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