Product image of Metoclopramidhydrochlorid Basi (Metoclopramide Hydrochloride) supplied by GNH India

Metoclopramidhydrochlorid Basi

Active Ingredient:
Metoclopramide Hydrochloride
Origin:
EU

Metoclopramidhydrochlorid Basi (Metoclopramide Hydrochloride)

Metoclopramide Hydrochloride, the active ingredient in Metoclopramidhydrochlorid Basi, is a dopamine antagonist / prokinetic presented as a sterile injectable solution for intramuscular and intravenous use. It is used to treat nausea and vomiting, gastroparesis, and postoperative nausea and vomiting in adult patients.

GNH India supplies Metoclopramidhydrochlorid Basi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Metoclopramide Hydrochloride acts on dopamine pathways and gastrointestinal motility to relieve several nausea‑related conditions.

  • Nausea and vomiting: reduces episodes by blocking dopamine receptors in the chemoreceptor trigger zone.
  • Gastroparesis: enhances gastric emptying and alleviates related symptoms.
  • Post‑operative nausea and vomiting: prevents and treats nausea following surgical procedures.

How It Works

  • Metoclopramide Hydrochloride antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and throughout the gastrointestinal tract, which diminishes the emetic signal. Simultaneously, it promotes acetylcholine release, increasing smooth‑muscle contractility and accelerating gastric emptying, thereby exerting both antiemetic and pro‑kinetic effects.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Drowsiness: mild sedation experienced by many patients.
  • Restlessness: occasional feelings of inner tension or agitation.
  • Diarrhea: loose stools occurring shortly after administration.
  • Dry mouth: reduced salivation leading to throat discomfort.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Tardive dyskinesia: persistent, potentially irreversible facial or limb movements.
  • Neuroleptic malignant syndrome: rare but life‑threatening hyperthermia and rigidity.
  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate specific risk factors and monitor patients closely.

  • Assess renal function: dose adjustment may be needed in impaired clearance.
  • Monitor for extrapyramidal symptoms: watch for muscle rigidity or abnormal movements.
  • Use caution in patients with depression: may exacerbate mood disorders.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Metoclopramide Hydrochloride can alter the effect of several concomitant medicines.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): increased risk of extrapyramidal symptoms.
  • MAO inhibitors: potential for hypertensive crisis.
  • CNS depressants (e.g., opioids, benzodiazepines): enhanced sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., codeine): altered metabolism may affect efficacy.
  • Anticholinergic agents: may diminish the pro‑kinetic benefit of metoclopramide.

Frequently Asked Questions

Metoclopramidhydrochlorid Basi, containing metoclopramide hydrochloride, is prescribed to manage nausea and vomiting, treat gastroparesis by improving gastric emptying, and prevent or treat postoperative nausea and vomiting in adult patients.

The drug blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the sensation of nausea. It also enhances acetylcholine release in the gastrointestinal tract, stimulating smooth‑muscle activity and speeding gastric emptying.

The specific dose and administration schedule are determined by the prescribing clinician based on the patient’s condition, age, weight, and renal function. Healthcare professionals should follow local prescribing guidelines.

Safety data for metoclopramide in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Metoclopramide differs from many antiemetics such as ondansetron, which primarily blocks serotonin receptors. Metoclopramide’s dopamine antagonism and pro‑kinetic activity make it useful for both nausea control and gastric motility, whereas drugs like ondansetron lack the pro‑kinetic effect.

Store the injectable solution below 25 °C in its original packaging, protecting it from moisture and direct light. Do not freeze the product, and keep the vial tightly sealed when not in use.

The medication is supplied as a sterile solution for intramuscular or intravenous injection. Administration technique, rate, and site are determined by the treating clinician according to the indication and patient condition.

Serious adverse events include extrapyramidal reactions such as dystonia, tardive dyskinesia, neuroleptic malignant syndrome, severe depression, seizures, and anaphylactic reactions. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to metoclopramide or any component of the formulation, those with pheochromocytoma, or individuals taking contraindicated medications (e.g., certain antipsychotics) should avoid this drug. Clinical judgment is essential for all contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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