Metoclopramidi Hydrochloridum Noridem (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide works by blocking dopamine D2 receptors in the brain’s chemoreceptor trigger zone and in the gastrointestinal tract, which lifts inhibitory signals and stimulates coordinated gastric contractions. It also antagonises serotonin 5‑HT3 receptors, adding to its anti‑emetic activity.

The appropriate dose of metoclopramide is determined by the prescribing clinician based on the patient’s age, weight, renal function, the severity of symptoms, and the specific indication being treated. No fixed regimen is provided here.

Safety data for metoclopramide in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Metoclopramide differs from many antiemetics by combining dopamine D2 antagonism with serotonin 5‑HT3 blockade and pro‑kinetic activity. Compared with pure serotonin antagonists (e.g., ondansetron), it also enhances gastric motility, but it carries a higher risk of extrapyramidal side effects, especially with prolonged use.

The injectable solution should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Use aseptic technique when preparing for intramuscular or intravenous administration.

Metoclopramidi Hydrochloridum Noridem is administered by a healthcare professional via intramuscular or intravenous injection, according to the prescriber’s instructions. The route, rate of infusion and duration are individualized based on the clinical situation.

Serious adverse reactions include extrapyramidal movements such as acute dystonia, tardive dyskinesia with long‑term use, neuroleptic malignant syndrome, severe depression or suicidal thoughts, anaphylaxis, and cardiac arrhythmias. Immediate medical attention is required if any of these occur.

Metoclopramide is contraindicated in patients with known hypersensitivity to the drug, in those with pheochromocytoma, and should be used with extreme caution or avoided in individuals with Parkinson’s disease, seizure disorders, severe renal impairment, or a history of extrapyramidal reactions.