Product image of Metodura Znt (Metoprolol Tartrate) supplied by GNH India

Metodura Znt

Active Ingredient:
Metoprolol Tartrate
Origin:
EU

Metodura Znt (Metoprolol Tartrate)

Metoprolol Tartrate, the active ingredient in Metodura Znt, is a beta blocker presented as an oral tablet for oral use. It treats hypertension, angina, post‑myocardial infarction care, chronic heart failure and certain cardiac arrhythmias in adult patients.

GNH India supplies Metodura Znt as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Germany Gmbh

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Indications & Clinical Uses

Metoprolol Tartrate is employed to manage cardiovascular conditions that involve elevated blood pressure or cardiac workload.

  • Hypertension: lowers systemic blood pressure by reducing heart rate and myocardial contractility.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: improves survival by limiting arrhythmias and remodeling.
  • Chronic heart failure: enhances ventricular function and reduces hospitalisation.
  • Cardiac arrhythmias: controls rate in supraventricular tachycardia and atrial fibrillation.

How It Works

  • Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in cardiac tissue, inhibiting the effects of endogenous catecholamines. This antagonism reduces heart rate, myocardial contractility, and consequently cardiac output, leading to lower arterial pressure and decreased myocardial oxygen consumption.

Side Effects

Metoprolol Tartrate may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Fatigue or tiredness.
  • Dizziness or light‑headedness.
  • Cold extremities (hands and feet).
  • Gastrointestinal discomfort such as nausea.
  • Bradycardia (slow heart rate).
  • Sleep disturbances or vivid dreams.

Serious or Rare Side Effects

  • Severe bradycardia or heart block.
  • Marked hypotension.
  • Bronchospasm, especially in patients with asthma.
  • Depression or mood changes.
  • Allergic reactions including rash or angioedema.
  • Worsening heart failure.

Precautions & Warnings

When prescribing Metodura Znt, clinicians should consider several safety aspects.

  • Assess cardiac function: evaluate baseline heart rate and blood pressure before initiation.
  • Monitor for bronchospasm: avoid in patients with uncontrolled asthma or severe chronic obstructive pulmonary disease.
  • Review diabetes therapy: beta‑blockade may mask hypoglycaemia symptoms.
  • Adjust in renal/hepatic impairment: dose may need modification in reduced clearance.
  • Discontinue gradually: abrupt cessation can precipitate rebound hypertension or tachycardia.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metodura Znt can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Calcium channel blockers (e.g., verapamil, diltiazem): risk of profound bradycardia.
  • Clonidine: abrupt withdrawal may cause severe rebound hypertension.
  • Other antihypertensives (e.g., ACE inhibitors, diuretics): additive blood‑pressure lowering effect.
  • Anti‑arrhythmic agents (e.g., amiodarone): may increase plasma concentrations of metoprolol.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may attenuate antihypertensive response.
  • Antidepressants (e.g., SSRIs, SNRIs): potential increase in metoprolol levels.
  • Potassium‑sparing diuretics: heightened risk of hyperkalaemia.

Frequently Asked Questions

Metodura Znt contains metoprolol tartrate, a beta‑blocker indicated for the treatment of high blood pressure, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias. It helps control heart rate and reduces the workload on the heart.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, preventing adrenaline and noradrenaline from binding. This reduces heart rate, contractile force, and cardiac output, which together lower blood pressure and myocardial oxygen demand.

The appropriate dose of Metodura Znt is determined by the prescribing clinician based on the patient’s condition, response, and any co‑existing medical issues. Dosage regimens are individualized and should follow the prescriber’s instructions.

The safety of Metodura Znt in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and discuss any concerns with the patient before prescribing.

To order Metodura Znt, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metodura Znt (metoprolol tartrate) is a cardio‑selective β1‑blocker, offering a lower risk of bronchospasm compared with non‑selective agents such as propranolol. Its pharmacokinetic profile provides reliable blood‑pressure control and is often preferred for patients with concomitant respiratory disease.

Store Metodura Znt at ambient temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability.

Metodura Znt is taken orally, usually as a tablet swallowed whole with a glass of water. It may be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals.

Serious adverse effects include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing, or swelling of the face or throat.

Metodura Znt is contraindicated in patients with known severe bradycardia, second‑ or third‑degree atrioventricular block, uncompensated heart failure, or uncontrolled asthma/COPD. Caution is also advised for individuals with severe hepatic impairment or those taking certain interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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