Product image of Metohexal (Metoprolol Succinate) supplied by GNH India

Metohexal

Active Ingredient:
Metoprolol Succinate
Origin:
EU

Metohexal (Metoprolol Succinate)

Metoprolol succinate, the active ingredient in Metohexal, is a beta blocker presented as an oral tablet for oral use. It lowers blood pressure, reduces myocardial oxygen demand, and is employed in the management of hypertension, angina, and heart failure in adult patients.
GNH India supplies Metohexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal A/S

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Metohexal, a selective β1‑adrenergic blocker, is used in several cardiovascular conditions.

  • Hypertension: lowers elevated arterial pressure and reduces cardiovascular risk.
  • Angina pectoris: decreases myocardial oxygen consumption, relieving chest pain.
  • Chronic heart failure: improves ventricular function and reduces hospitalizations.
  • Post‑myocardial infarction prophylaxis: lowers the chance of recurrent cardiac events.

How It Works

  • Metoprolol succinate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, which diminishes sympathetic stimulation. This results in a reduced heart rate, decreased myocardial contractility, and lowered renin release from the kidneys, collectively contributing to decreased blood pressure and reduced myocardial oxygen demand.

Side Effects

Metohexal may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma
  • Allergic reactions (rash, angioedema)
  • Depression or mood changes
  • Worsening heart failure symptoms

Precautions & Warnings

Before initiating Metohexal, several safety considerations should be observed.

  • Monitor blood pressure: ensure adequate control and avoid hypotension.
  • Assess heart rate: watch for excessive bradycardia.
  • Use caution in asthma or chronic obstructive pulmonary disease: β1‑selectivity may not fully prevent bronchospasm.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension or tachycardia.
  • Adjust dose in renal impairment: consider reduced clearance.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Metohexal can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers (e.g., propranolol) – additive cardiac depression.
  • Calcium channel blockers verapamil or diltiazem – risk of severe bradycardia.
  • Clonidine – may cause hypertensive crisis if stopped abruptly.
  • Insulin or oral hypoglycemics – mask hypoglycemia symptoms.

Moderate Interactions (Monitor Closely)

  • Diuretics – may enhance hypotensive effect.
  • ACE inhibitors or ARBs – monitor for additive blood pressure lowering.
  • NSAIDs – may reduce antihypertensive efficacy.
  • Certain antidepressants (SSRIs) – watch for heart rate changes.

Frequently Asked Questions

Metohexal contains metoprolol succinate, a selective β1‑adrenergic blocker that is prescribed for hypertension, angina pectoris, chronic heart failure, and for reducing the risk of recurrent events after a myocardial infarction. It works by lowering heart rate and blood pressure, thereby decreasing the workload on the heart.

Metoprolol succinate blocks β1‑adrenergic receptors primarily in the heart, which reduces the effects of adrenaline and noradrenaline. This leads to a slower heart rate, decreased contractile force, and reduced renin release from the kidneys, collectively lowering blood pressure and myocardial oxygen demand.

The dose of Metohexal is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. The prescriber determines the appropriate strength, frequency, and titration schedule, which may be adjusted during therapy.

Safety data for metoprolol succinate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Metohexal product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Metohexal (metoprolol succinate) is a cardio‑selective β1‑blocker, offering a favorable profile for patients with respiratory conditions compared with non‑selective agents. Its extended‑release formulation provides once‑daily dosing, which can improve adherence relative to short‑acting beta blockers that require multiple daily doses.

Metohexal should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Metohexal is taken orally, usually once daily due to its extended‑release formulation. It should be swallowed whole with a glass of water and not chewed, crushed, or split, unless the prescriber specifically advises otherwise.

Serious risks include severe bradycardia, heart block, profound hypotension, bronchospasm in susceptible individuals, and worsening heart failure. Patients should be monitored for these events, especially during dose initiation or when combined with interacting medications.

Metohexal is contraindicated in patients with known hypersensitivity to metoprolol or any component of the formulation, in those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, and in patients with uncompensated heart failure or cardiogenic shock.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.