Product image of Metohexal (Metoprolol Tartrate Ph. Eur.) supplied by GNH India

Metohexal

Active Ingredient:
Metoprolol Tartrate Ph. Eur.
Origin:
EU

Metohexal (Metoprolol Tartrate Ph. Eur.)

Metoprolol Tartrate, the active ingredient in Metohexal, is a beta‑blocker presented as an oral tablet for oral use. It treats hypertension, angina pectoris, post‑myocardial infarction, chronic heart failure and certain cardiac arrhythmias in adult patients.

GNH India supplies Metohexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

  • Metohexal is a beta‑blocker that acts on the cardiovascular system to control blood pressure and reduce cardiac workload.
  • Hypertension: lowers systemic blood pressure by decreasing heart rate and cardiac output.
  • Angina pectoris: reduces myocardial oxygen demand, relieving chest pain.
  • Post‑myocardial infarction: helps prevent recurrent cardiac events by stabilising heart rhythm.
  • Chronic heart failure: improves survival by decreasing ventricular workload.
  • Certain cardiac arrhythmias: controls heart rate and rhythm in selected arrhythmic conditions.

How It Works

  • Metoprolol Tartrate selectively antagonises β1‑adrenergic receptors in cardiac tissue, inhibiting sympathetic stimulation. This reduces heart rate, myocardial contractility, and cardiac output, leading to lower blood pressure and decreased myocardial oxygen consumption, which underpins its antihypertensive, anti‑anginal, and heart‑failure benefits.

Side Effects

Metohexal may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Fatigue or tiredness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities or peripheral vasoconstriction
  • Gastrointestinal upset (nausea, abdominal discomfort)
  • Sleep disturbances or vivid dreams

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm, especially in patients with asthma
  • Acute decompensated heart failure
  • Allergic reactions such as rash or angioedema
  • Cardiogenic shock in rare cases

Precautions & Warnings

  • Before initiating Metohexal, clinicians should evaluate patient-specific risk factors and monitor therapy closely.
  • Cardiovascular assessment: check baseline heart rate and blood pressure.
  • Respiratory status: avoid in uncontrolled asthma or severe chronic obstructive pulmonary disease.
  • Diabetes monitoring: be aware of masked hypoglycaemia symptoms.
  • Pregnancy counseling: discuss potential risks, as the drug is category C.
  • Drug discontinuation: taper gradually to prevent rebound hypertension.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Metohexal can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (verapamil, diltiazem): increased risk of AV block.
  • Abrupt clonidine withdrawal: may precipitate severe rebound hypertension.

Moderate Interactions (Monitor Closely)

  • Diuretics: enhanced hypotensive effect, monitor electrolytes.
  • ACE inhibitors or ARBs: watch renal function and potassium levels.
  • Antidiabetic agents: possible masking of hypoglycaemia signs, adjust monitoring.

Frequently Asked Questions

Metohexal contains metoprolol tartrate, a beta‑blocker indicated for the management of hypertension, angina pectoris, post‑myocardial infarction care, chronic heart failure, and certain cardiac arrhythmias. It helps lower blood pressure, reduce chest pain, and improve heart function in adult patients.

Metoprolol Tartrate selectively blocks β1‑adrenergic receptors in the heart, diminishing the effects of adrenaline. This leads to a slower heart rate, reduced contractility, and lower cardiac output, which together lower blood pressure and decrease the heart’s oxygen demand.

The appropriate dose of Metohexal is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the dosing instructions provided by their healthcare professional and not adjust the dose on their own.

Metohexal is classified as pregnancy category C, meaning risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician, as the drug may be excreted in breast milk.

To order Metohexal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Metohexal (metoprolol tartrate) is a cardio‑selective β1‑blocker, offering a favorable profile for patients with respiratory concerns compared with non‑selective agents. Its once‑ or twice‑daily dosing and proven efficacy in heart failure and post‑MI settings make it a common choice, though individual response and tolerability guide final selection.

Metohexal tablets should be stored at room temperature below 25 °C, in the original container, protected from moisture and direct sunlight. Keep out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

Metohexal is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the prescribing physician’s guidance on timing relative to meals to maintain consistent absorption.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in susceptible individuals, and acute decompensated heart failure. Patients should seek immediate medical attention if they experience fainting, extreme fatigue, difficulty breathing, or rapid weight gain.

Metohexal is contraindicated in patients with severe bradycardia, second‑ or third‑degree AV block without a pacemaker, cardiogenic shock, overt heart failure, and uncontrolled asthma or severe chronic obstructive pulmonary disease. It should also be avoided in individuals with known hypersensitivity to metoprolol or any excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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