Product image of Metohexal Succ (Metoprolol Succinate) supplied by GNH India

Metohexal Succ

Active Ingredient:
Metoprolol Succinate
Origin:
EU

Metohexal Succ (Metoprolol Succinate)

Metoprolol succinate, the active ingredient in Metohexal Succ, is a beta blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, relieve angina and improve outcomes in heart failure and post‑myocardial infarction patients.
GNH India supplies Metohexal Succ as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Metohexal Succ, a beta‑adrenergic blocker, is used in several cardiovascular conditions.

  • Hypertension: lowers systemic blood pressure and reduces cardiovascular risk.
  • Chronic stable angina: decreases myocardial oxygen demand, relieving chest pain.
  • Heart failure (reduced ejection fraction): improves ventricular function and survival.
  • Post‑myocardial infarction: reduces the risk of recurrent cardiac events and mortality.

How It Works

  • Metoprolol succinate selectively antagonizes β1‑adrenergic receptors in cardiac tissue, diminishing sympathetic stimulation. This results in decreased heart rate, reduced myocardial contractility, and lower cardiac output, which together lower blood pressure and myocardial oxygen consumption, supporting its antihypertensive, anti‑anginal, and heart‑failure benefits.

Side Effects

Metohexal Succ may cause a range of adverse reactions.

Common Side Effects

  • Fatigue: feeling of tiredness or reduced energy.
  • Dizziness or light‑headedness, especially when standing quickly.
  • Bradycardia: slower than normal heart rate.
  • Gastrointestinal upset such as nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe bradycardia or heart block requiring medical attention.
  • Marked hypotension leading to fainting or shock.
  • Bronchospasm or worsening of asthma symptoms.
  • Allergic reactions including rash, swelling or anaphylaxis.
  • Depression or mood changes that may need evaluation.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: adjust dose based on kidney function.
  • Asthma or COPD: use with caution due to potential bronchoconstriction.
  • Monitor heart rate and blood pressure regularly during treatment.
  • Avoid abrupt discontinuation to prevent rebound hypertension or tachycardia.
  • Diabetes: may mask hypoglycaemia symptoms; monitor glucose closely.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metohexal Succ can interact with several medicines.

Major Interactions (Avoid)

  • Non‑selective beta‑blockers: additive cardiac depression.
  • Calcium channel blockers (verapamil, diltiazem): risk of severe bradycardia.
  • Clonidine: abrupt withdrawal may cause hypertensive crisis.
  • Insulin or oral hypoglycemics: may mask hypoglycaemia signs.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: additive blood‑pressure lowering effect.
  • Diuretics: may enhance hypotensive response.
  • Certain antidepressants (e.g., SSRIs): potential for serotonin syndrome when combined with other serotonergic agents.

Frequently Asked Questions

Metohexal Succ contains metoprolol succinate, a beta‑blocker indicated for hypertension, chronic stable angina, heart failure with reduced ejection fraction, and post‑myocardial infarction management. It helps lower blood pressure, reduce chest pain, improve heart‑failure outcomes, and lower the risk of further cardiac events after a heart attack.

Metoprolol succinate selectively blocks β1‑adrenergic receptors in the heart, decreasing sympathetic stimulation. This leads to a slower heart rate, reduced contractility, and lower cardiac output, which together lower blood pressure and myocardial oxygen demand, providing therapeutic benefit in the listed cardiovascular conditions.

The appropriate dose of Metohexal Succ is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any comorbidities. Dosage may be started low and titrated upward, but exact regimens should only be set by a qualified healthcare professional.

Safety data for metoprolol succinate in pregnancy are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their physician, as the drug can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoprolol succinate is a selective β1‑blocker, offering cardiac‑focused effects with fewer respiratory side effects compared with non‑selective agents like propranolol. Its extended‑release formulation provides once‑daily dosing, which can improve adherence relative to shorter‑acting beta‑blockers that require multiple daily doses.

Metohexal Succ should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Metohexal Succ is taken orally, usually as a whole tablet with or without food. Patients should swallow the tablet with a full glass of water and follow the dosing schedule prescribed by their healthcare provider, avoiding crushing or chewing extended‑release tablets.

Serious risks include severe bradycardia, heart block, marked hypotension, bronchospasm in patients with obstructive airway disease, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid weight gain, swelling of the legs, or any signs of an allergic response.

Metohexal Succ is contraindicated in patients with known hypersensitivity to metoprolol or any excipients, those with severe bradycardia, second‑ or third‑degree heart block without a pacemaker, cardiogenic shock, or overt decompensated heart failure. Caution is also advised for individuals with uncontrolled asthma or severe peripheral vascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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