Product image of Metoject (Methotrexate) supplied by GNH India

Metoject

Active Ingredient:
Methotrexate
Origin:
EU

Metoject (Methotrexate)

Methotrexate, the active ingredient in Metoject, is an antimetabolite (folate antagonist) presented as a subcutaneous formulation for subcutaneous use. It is employed in the management of rheumatoid arthritis, psoriasis, psoriatic arthritis, acute lymphoblastic leukemia and other malignancies in patients as prescribed.
GNH India supplies Metoject as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medac Gesellschaft Für Klinische Spezialpräparate Mbh (Wedel)

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Methotrexate acts as a disease‑modifying agent across several inflammatory and oncologic pathways.

  • Rheumatoid arthritis: reduces joint inflammation and slows structural damage.
  • Psoriasis: improves skin lesions and decreases scaling.
  • Psoriatic arthritis: alleviates joint pain while treating skin symptoms.
  • Acute lymphoblastic leukemia: interferes with malignant cell proliferation.
  • Other malignancies: incorporated into chemotherapy regimens to inhibit tumor growth.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, decreasing tetrahydrofolate production and thereby limiting purine and pyrimidine synthesis. This reduction in DNA, RNA and protein synthesis impairs rapidly dividing cells, including immune cells and malignant clones, while also exerting anti‑inflammatory effects through adenosine release.

Side Effects

Methotrexate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea and vomiting: mild to moderate gastrointestinal upset.
  • Fatigue: persistent tiredness affecting daily activities.
  • Oral mucositis: soreness or ulceration of the mouth lining.
  • Mild elevation of liver enzymes: transient hepatic enzyme rise.

Serious or Rare Side Effects

  • Severe liver toxicity: potential hepatic failure requiring monitoring.
  • Pulmonary fibrosis: interstitial lung disease with breathlessness.
  • Bone marrow suppression: profound anemia, leukopenia or thrombocytopenia.
  • Renal failure: impaired kidney function leading to drug accumulation.

Precautions & Warnings

Methotrexate requires careful monitoring and specific safety measures.

  • Pregnancy contraindication: teratogenic; avoid use in pregnant or planning patients.
  • Renal function monitoring: adjust dose if creatinine clearance declines.
  • Liver function monitoring: regular tests to detect hepatotoxicity.
  • Hematologic monitoring: frequent blood counts to identify marrow suppression.
  • Hypersensitivity: discontinue if severe allergic reaction occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several drug classes that can alter its efficacy or toxicity.

Major Interactions (Avoid)

  • Nonsteroidal anti‑inflammatory drugs (NSAIDs): increase risk of renal toxicity.
  • Penicillins (e.g., ampicillin): may reduce renal clearance of methotrexate.
  • Sulfonamide antibiotics: additive bone‑marrow suppression.
  • Live vaccines: heightened infection risk due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Azathioprine or other immunosuppressants: enhanced myelosuppression.
  • Cyclosporine: may increase methotrexate levels.
  • Folic acid supplements: can reduce toxicity but may lessen efficacy; adjust under medical guidance.

Frequently Asked Questions

Metoject contains methotrexate and is prescribed for rheumatoid arthritis, psoriasis, psoriatic arthritis, acute lymphoblastic leukemia and other selected malignancies. It works by modifying disease activity and slowing progression in these inflammatory and oncologic conditions.

Methotrexate blocks the enzyme dihydrofolate reductase, reducing the formation of tetrahydrofolate needed for DNA, RNA and protein synthesis. This limits the proliferation of rapidly dividing cells, such as immune cells and cancer cells, and also triggers anti‑inflammatory pathways.

The dose of Metoject is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and treatment response. Only a qualified healthcare professional should determine the appropriate dosing regimen.

Methotrexate is classified as pregnancy category X because it is known to cause fetal harm and is contraindicated in pregnancy. It is also not recommended while breastfeeding, as it can be excreted in milk and affect the infant.

To request Metoject, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Metoject (methotrexate) is a first‑line conventional DMARD with a well‑established efficacy and safety profile. Compared with biologic agents, it is less expensive and administered subcutaneously, but may require more laboratory monitoring. Choice of therapy depends on disease severity, patient comorbidities and treatment goals.

Metoject should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Metoject is given by subcutaneous injection, typically into the abdomen or thigh. The injection site should be rotated to reduce local irritation, and the medication is administered by a healthcare professional or trained patient according to the prescriber's instructions.

Serious risks include severe liver toxicity, pulmonary fibrosis, bone‑marrow suppression leading to anemia or infection, and renal failure. Patients should be monitored regularly for liver enzymes, lung function, blood counts and kidney parameters to detect these complications early.

Metoject is contraindicated in pregnant women, individuals with known hypersensitivity to methotrexate, patients with severe renal or hepatic impairment, and those with active infections that could be worsened by immunosuppression. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Methotrexate

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT